GRID2

Glutamate receptor, ionotropic, delta 2, also known as GRID2, is a human gene.cite web | title = Entrez Gene: GRID2 glutamate receptor, ionotropic, delta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2895| accessdate = ]

PBB_Summary
section_title =
summary_text = Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.cite web | title = Entrez Gene: GRID2 glutamate receptor, ionotropic, delta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2895| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Araki K, Meguro H, Kushiya E, "et al." |title=Selective expression of the glutamate receptor channel delta 2 subunit in cerebellar Purkinje cells. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 3 |pages= 1267–76 |year= 1994 |pmid= 7506541 |doi= 10.1006/bbrc.1993.2614
*cite journal | author=Hu W, Zuo J, De Jager PL, Heintz N |title=The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22. |journal=Genomics |volume=47 |issue= 1 |pages= 143–5 |year= 1998 |pmid= 9465309 |doi= 10.1006/geno.1997.5108
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Roche KW, Ly CD, Petralia RS, "et al." |title=Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses. |journal=J. Neurosci. |volume=19 |issue= 10 |pages= 3926–34 |year= 1999 |pmid= 10234023 |doi=
*cite journal | author=Hironaka K, Umemori H, Tezuka T, "et al." |title=The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 16167–73 |year= 2000 |pmid= 10748123 |doi= 10.1074/jbc.M909302199
*cite journal | author=Miyagi Y, Yamashita T, Fukaya M, "et al." |title=Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit. |journal=J. Neurosci. |volume=22 |issue= 3 |pages= 803–14 |year= 2002 |pmid= 11826110 |doi=
*cite journal | author=Ly CD, Roche KW, Lee HK, Wenthold RJ |title=Identification of rat EMAP, a delta-glutamate receptor binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 1 |pages= 85–90 |year= 2002 |pmid= 11829466 |doi= 10.1006/bbrc.2002.6413
*cite journal | author=Yue Z, Horton A, Bravin M, "et al." |title=A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. |journal=Neuron |volume=35 |issue= 5 |pages= 921–33 |year= 2002 |pmid= 12372286 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kohda K, Kamiya Y, Matsuda S, "et al." |title=Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors. |journal=Brain Res. Mol. Brain Res. |volume=110 |issue= 1 |pages= 27–37 |year= 2003 |pmid= 12573530 |doi=
*cite journal | author=Yap CC, Muto Y, Kishida H, "et al." |title=PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 4 |pages= 1122–8 |year= 2003 |pmid= 12589829 |doi=
*cite journal | author=Sonoda T, Mochizuki C, Yamashita T, "et al." |title=Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA. |journal=Biochem. Biophys. Res. Commun. |volume=350 |issue= 3 |pages= 748–52 |year= 2006 |pmid= 17027646 |doi= 10.1016/j.bbrc.2006.09.109

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