Glutamate receptor, ionotropic, kainate 5, also known as GRIK5, is a human gene.cite web | title = Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5| url =| accessdate = ]

section_title =
summary_text = This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.cite web | title = Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5| url =| accessdate = ]

ee also

* Kainate receptor


Further reading

citations =
*cite journal | author=Kamboj RK, Schoepp DD, Nutt S, "et al." |title=Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit. |journal=Mol. Pharmacol. |volume=42 |issue= 1 |pages= 10–5 |year= 1992 |pmid= 1321949 |doi=
*cite journal | author=Szpirer C, Molné M, Antonacci R, "et al." |title=The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 25 |pages= 11849–53 |year= 1995 |pmid= 7527545 |doi=
*cite journal | author=Cauley K, Kukekov V, Young D |title=Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture. |journal=J. Neurosci. Res. |volume=47 |issue= 3 |pages= 311–21 |year= 1997 |pmid= 9039653 |doi=
*cite journal | author=Porter RH, Eastwood SL, Harrison PJ |title=Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. |journal=Brain Res. |volume=751 |issue= 2 |pages= 217–31 |year= 1997 |pmid= 9099808 |doi=
*cite journal | author=Ripellino JA, Neve RL, Howe JR |title=Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. |journal=Neuroscience |volume=82 |issue= 2 |pages= 485–97 |year= 1998 |pmid= 9466455 |doi=
*cite journal | author=Garcia EP, Mehta S, Blair LA, "et al." |title=SAP90 binds and clusters kainate receptors causing incomplete desensitization. |journal=Neuron |volume=21 |issue= 4 |pages= 727–39 |year= 1998 |pmid= 9808460 |doi=
*cite journal | author=Mehta S, Wu H, Garner CC, Marshall J |title=Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16092–9 |year= 2001 |pmid= 11279111 |doi= 10.1074/jbc.M100643200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kohda K, Kamiya Y, Matsuda S, "et al." |title=Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors. |journal=Brain Res. Mol. Brain Res. |volume=110 |issue= 1 |pages= 27–37 |year= 2003 |pmid= 12573530 |doi=
*cite journal | author=Hayes DM, Braud S, Hurtado DE, "et al." |title=Trafficking and surface expression of the glutamate receptor subunit, KA2. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 1 |pages= 8–13 |year= 2003 |pmid= 14511640 |doi=
*cite journal | author=Kamm C, Leung J, Joseph S, "et al." |title=Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene. |journal=Mov. Disord. |volume=19 |issue= 7 |pages= 845–7 |year= 2004 |pmid= 15254951 |doi= 10.1002/mds.20095

External links


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