P2RX4

Purinergic receptor P2X, ligand-gated ion channel, 4
Identifiers
Symbols	P2RX4; P2X4; P2X4R
External IDs	OMIM: 600846 MGI: 1338859 HomoloGene: 1923 GeneCards: P2RX4 Gene
Gene Ontology Molecular function • purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • receptor activity • extracellular ATP-gated cation channel activity • receptor binding • ion channel activity • copper ion binding • ATP binding • drug binding • zinc ion binding • protein homodimerization activity • cadherin binding Cellular component • plasma membrane • integral to plasma membrane • postsynaptic density • membrane • cell junction • axon • neuronal cell body • terminal button • dendritic spine • apical part of cell • synapse • perinuclear region of cytoplasm Biological process • tissue homeostasis • regulation of sodium ion transport • transport • ion transport • response to stress • signal transduction • regulation of blood pressure • positive regulation of calcium ion transport into cytosol • positive regulation of calcium ion transport into cytosol • negative regulation of cardiac muscle hypertrophy • regulation of action potential in neuron • sensory perception of pain • positive regulation of prostaglandin secretion • response to ATP • response to fluid shear stress • purinergic nucleotide receptor signaling pathway • purinergic nucleotide receptor signaling pathway • endothelial cell activation • vasodilation • regulation of apoptosis • positive regulation of nitric oxide biosynthetic process • positive regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • protein homooligomerization • membrane depolarization • positive regulation of calcium ion transport • regulation of cardiac muscle contraction • relaxation of cardiac muscle • regulation of excitatory postsynaptic membrane potential Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5025	18438
Ensembl	ENSG00000135124	ENSMUSG00000029470
UniProt	Q99571	Q3TR36
RefSeq (mRNA)	NM_002560	NM_011026.2
RefSeq (protein)	NP_002551	NP_035156.2
Location (UCSC)	Chr 12: 121.65 – 121.67 Mb	Chr 5: 123.16 – 123.18 Mb
PubMed search	[1]	[2]

P2X purinoceptor 4 is a protein that in humans is encoded by the P2RX4 gene.^[1][2]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.^[2]

See also

• P2X receptor

References

1. ^ Garcia-Guzman M, Soto F, Gomez-Hernandez JM, Lund PE, Stuhmer W (Feb 1997). "Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue". Mol Pharmacol 51 (1): 109–18. PMID 9016352. 
2. ^ ^{a b} "Entrez Gene: P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5025. 

Further reading

• North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Garcia-Guzman M, Stühmer W, Soto F (1997). "Molecular characterization and pharmacological properties of the human P2X3 purinoceptor". Brain Res. Mol. Brain Res. 47 (1–2): 59–66. doi:10.1016/S0169-328X(97)00036-3. PMID 9221902. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Korenaga R, Yamamoto K, Ohura N, et al. (2001). "Sp1-mediated downregulation of P2X4 receptor gene transcription in endothelial cells exposed to shear stress". Am. J. Physiol. Heart Circ. Physiol. 280 (5): H2214–21. PMID 11299224. 
• Glass R, Loesch A, Bodin P, Burnstock G (2002). "P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells". Cell. Mol. Life Sci. 59 (5): 870–81. doi:10.1007/s00018-002-8474-y. PMID 12088286. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Yamamoto K, Sokabe T, Ohura N, et al. (2003). "Endogenously released ATP mediates shear stress-induced Ca2+ influx into pulmonary artery endothelial cells". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H793–803. doi:10.1152/ajpheart.01155.2002. PMID 12714321. 
• Yeung D, Kharidia R, Brown SC, Górecki DC (2004). "Enhanced expression of the P2X4 receptor in Duchenne muscular dystrophy correlates with macrophage invasion". Neurobiol. Dis. 15 (2): 212–20. doi:10.1016/j.nbd.2003.10.014. PMID 15006691. 
• Yang A, Sonin D, Jones L, et al. (2004). "A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy". Am. J. Physiol. Heart Circ. Physiol. 287 (3): H1096–103. doi:10.1152/ajpheart.00079.2004. PMID 15130891. 
• Brown DA, Bruce JI, Straub SV, Yule DI (2004). "cAMP potentiates ATP-evoked calcium signaling in human parotid acinar cells". J. Biol. Chem. 279 (38): 39485–94. doi:10.1074/jbc.M406201200. PMID 15262999. 
• Fountain SJ, North RA (2006). "A C-terminal lysine that controls human P2X4 receptor desensitization". J. Biol. Chem. 281 (22): 15044–9. doi:10.1074/jbc.M600442200. PMID 16533808. 
• Jelínková I, Yan Z, Liang Z, et al. (2006). "Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation". Biochem. Biophys. Res. Commun. 349 (2): 619–25. doi:10.1016/j.bbrc.2006.08.084. PMID 16949036. 
• Solini A, Santini E, Chimenti D, et al. (2007). "Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4". Am. J. Physiol. Renal Physiol. 292 (5): F1537–47. doi:10.1152/ajprenal.00440.2006. PMID 17264311. 

External links

• MeSH P2RX4+protein,+human

Ionotropic glutamates

Ligand-gated only	AMPA (1, 2, 3, 4) · Kainate (1, 2, 3, 4, 5)
Voltage- and ligand-gated	NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
‘Orphan’	GluD (δ1, δ2)

ATP-gated channels

Purinergic receptors

P2X (1, 2, 3, 4, 5, 6, 7)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)