GRIK2

Glutamate receptor, ionotropic, kainate 2, also known as GRIK2, is a human gene.cite web | title = Entrez Gene: GRIK2 glutamate receptor, ionotropic, kainate 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2898| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a subunit of a kainate glutamate receptor. Glutamate receptors mediate the majority of excitatory neurotransmission in the brain. This receptor may have a role in synaptic plasticity and may be important for learning and memory. It also may be involved in the transmission of light information from the retina to the hypothalamus. The structure and function of the encoded protein is changed by RNA editing. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.cite web | title = Entrez Gene: GRIK2 glutamate receptor, ionotropic, kainate 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2898| accessdate = ]

ee also

* Kainate receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Seeburg PH, Higuchi M, Sprengel R |title=RNA editing of brain glutamate receptor channels: mechanism and physiology. |journal=Brain Res. Brain Res. Rev. |volume=26 |issue= 2-3 |pages= 217–29 |year= 1998 |pmid= 9651532 |doi=
*cite journal | author=Paschen W, Hedreen JC, Ross CA |title=RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue. |journal=J. Neurochem. |volume=63 |issue= 5 |pages= 1596–602 |year= 1994 |pmid= 7523595 |doi=
*cite journal | author=Hoo KH, Nutt SL, Fletcher EJ, "et al." |title=Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit. |journal=Recept. Channels |volume=2 |issue= 4 |pages= 327–37 |year= 1995 |pmid= 7536611 |doi=
*cite journal | author=Sander T, Janz D, Ramel C, "et al." |title=Refinement of map position of the human GluR6 kainate receptor gene (GRIK2) and lack of association and linkage with idiopathic generalized epilepsies. |journal=Neurology |volume=45 |issue= 9 |pages= 1713–20 |year= 1995 |pmid= 7675232 |doi=
*cite journal | author=Nutt SL, Kamboj RK |title=RNA editing of human kainate receptor subunits. |journal=Neuroreport |volume=5 |issue= 18 |pages= 2625–9 |year= 1995 |pmid= 7696618 |doi=
*cite journal | author=Paschen W, Blackstone CD, Huganir RL, Ross CA |title=Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment. |journal=Genomics |volume=20 |issue= 3 |pages= 435–40 |year= 1994 |pmid= 8034316 |doi= 10.1006/geno.1994.1198
*cite journal | author=Raymond LA, Blackstone CD, Huganir RL |title=Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase. |journal=Nature |volume=361 |issue= 6413 |pages= 637–41 |year= 1993 |pmid= 8094892 |doi= 10.1038/361637a0
*cite journal | author=Roche KW, Raymond LA, Blackstone C, Huganir RL |title=Transmembrane topology of the glutamate receptor subunit GluR6. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11679–82 |year= 1994 |pmid= 8163463 |doi=
*cite journal | author=Taverna FA, Wang LY, MacDonald JF, Hampson DR |title=A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 14159–64 |year= 1994 |pmid= 8188697 |doi=
*cite journal | author=Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS |title=Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1332–9 |year= 1994 |pmid= 8288598 |doi=
*cite journal | author=Pickering DS, Taverna FA, Salter MW, Hampson DR |title=Palmitoylation of the GluR6 kainate receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 26 |pages= 12090–4 |year= 1996 |pmid= 8618850 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Porter RH, Eastwood SL, Harrison PJ |title=Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. |journal=Brain Res. |volume=751 |issue= 2 |pages= 217–31 |year= 1997 |pmid= 9099808 |doi=
*cite journal | author=Rubinsztein DC, Leggo J, Chiano M, "et al." |title=Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 8 |pages= 3872–6 |year= 1997 |pmid= 9108071 |doi=
*cite journal | author=Ripellino JA, Neve RL, Howe JR |title=Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. |journal=Neuroscience |volume=82 |issue= 2 |pages= 485–97 |year= 1998 |pmid= 9466455 |doi=
*cite journal | author=Garcia EP, Mehta S, Blair LA, "et al." |title=SAP90 binds and clusters kainate receptors causing incomplete desensitization. |journal=Neuron |volume=21 |issue= 4 |pages= 727–39 |year= 1998 |pmid= 9808460 |doi=
*cite journal | author=Leuschner WD, Hoch W |title=Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16907–16 |year= 1999 |pmid= 10358037 |doi=
*cite journal | author=Smith HJ |title=The introduction of MR in the Nordic countries with special reference to Norway: central control versus local initiatives. |journal=Journal of magnetic resonance imaging : JMRI |volume=13 |issue= 4 |pages= 639–44 |year= 2001 |pmid= 11276111 |doi=
*cite journal | author=Mehta S, Wu H, Garner CC, Marshall J |title=Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16092–9 |year= 2001 |pmid= 11279111 |doi= 10.1074/jbc.M100643200

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes