GRIA1

Glutamate receptor, ionotropic, AMPA 1, also known as GRIA1, is a human gene.cite web | title = Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2890| accessdate = ]

PBB_Summary
section_title =
summary_text = Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.cite web | title = Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2890| accessdate = ]

ee also

* AMPA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sun W, Ferrer-Montiel AV, Schinder AF, "et al." |title=Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1443–7 |year= 1992 |pmid= 1311100 |doi=
*cite journal | author=McNamara JO, Eubanks JH, McPherson JD, "et al." |title=Chromosomal localization of human glutamate receptor genes. |journal=J. Neurosci. |volume=12 |issue= 7 |pages= 2555–62 |year= 1992 |pmid= 1319477 |doi=
*cite journal | author=Potier MC, Spillantini MG, Carter NP |title=The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. |journal=DNA Seq. |volume=2 |issue= 4 |pages= 211–8 |year= 1992 |pmid= 1320959 |doi=
*cite journal | author=Puckett C, Gomez CM, Korenberg JR, "et al." |title=Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7557–61 |year= 1991 |pmid= 1652753 |doi=
*cite journal | author=Yakel JL, Vissavajjhala P, Derkach VA, "et al." |title=Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1376–80 |year= 1995 |pmid= 7877986 |doi=
*cite journal | author=Eastwood SL, Burnet PW, Beckwith J, "et al." |title=AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus. |journal=Neuroreport |volume=5 |issue= 11 |pages= 1325–8 |year= 1994 |pmid= 7919190 |doi=
*cite journal | author=Roche KW, Raymond LA, Blackstone C, Huganir RL |title=Transmembrane topology of the glutamate receptor subunit GluR6. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11679–82 |year= 1994 |pmid= 8163463 |doi=
*cite journal | author=McLaughlin DP, Cheetham ME, Kerwin RW |title=Expression of alternatively-spliced glutamate receptors in human hippocampus. |journal=Eur. J. Pharmacol. |volume=244 |issue= 1 |pages= 89–92 |year= 1993 |pmid= 8420792 |doi=
*cite journal | author=Roche KW, O'Brien RJ, Mammen AL, "et al." |title=Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. |journal=Neuron |volume=16 |issue= 6 |pages= 1179–88 |year= 1996 |pmid= 8663994 |doi=
*cite journal | author=Brakeman PR, Lanahan AA, O'Brien R, "et al." |title=Homer: a protein that selectively binds metabotropic glutamate receptors. |journal=Nature |volume=386 |issue= 6622 |pages= 284–8 |year= 1997 |pmid= 9069287 |doi= 10.1038/386284a0
*cite journal | author=Barria A, Derkach V, Soderling T |title=Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 32727–30 |year= 1998 |pmid= 9407043 |doi=
*cite journal | author=Ripellino JA, Neve RL, Howe JR |title=Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. |journal=Neuroscience |volume=82 |issue= 2 |pages= 485–97 |year= 1998 |pmid= 9466455 |doi=
*cite journal | author=Leonard AS, Davare MA, Horne MC, "et al." |title=SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. |journal=J. Biol. Chem. |volume=273 |issue= 31 |pages= 19518–24 |year= 1998 |pmid= 9677374 |doi=
*cite journal | author=Xiao B, Tu JC, Petralia RS, "et al." |title=Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. |journal=Neuron |volume=21 |issue= 4 |pages= 707–16 |year= 1998 |pmid= 9808458 |doi=
*cite journal | author=Montague AA, Greer CA |title=Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb. |journal=J. Comp. Neurol. |volume=405 |issue= 2 |pages= 233–46 |year= 1999 |pmid= 10023812 |doi=
*cite journal | author=Leuschner WD, Hoch W |title=Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16907–16 |year= 1999 |pmid= 10358037 |doi=
*cite journal | author=Shi SH, Hayashi Y, Petralia RS, "et al." |title=Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. |journal=Science |volume=284 |issue= 5421 |pages= 1811–6 |year= 1999 |pmid= 10364548 |doi=
*cite journal | author=Rubio ME, Wenthold RJ |title=Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors. |journal=J. Neurochem. |volume=73 |issue= 3 |pages= 942–8 |year= 1999 |pmid= 10461883 |doi=
*cite journal | author=Mahlknecht U, Bucala R, Hoelzer D, Verdin E |title=High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 3-4 |pages= 237–9 |year= 2000 |pmid= 10575214 |doi=
*cite journal | author=Stinehelfer S, Vruwink M, Burette A |title=Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex. |journal=Brain Res. |volume=861 |issue= 1 |pages= 37–44 |year= 2000 |pmid= 10751563 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes