GRIA3

Glutamate receptor, ionotrophic, AMPA 3, also known as GRIA3, is a human gene.cite web | title = Entrez Gene: GRIA3 glutamate receptor, ionotrophic, AMPA 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2892| accessdate = ]

PBB_Summary
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summary_text = Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternative splicing at this locus results in several different isoforms which may vary in their signal transduction properties.cite web | title = Entrez Gene: GRIA3 glutamate receptor, ionotrophic, AMPA 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2892| accessdate = ]

ee also

* AMPA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=McNamara JO, Eubanks JH, McPherson JD, "et al." |title=Chromosomal localization of human glutamate receptor genes. |journal=J. Neurosci. |volume=12 |issue= 7 |pages= 2555–62 |year= 1992 |pmid= 1319477 |doi=
*cite journal | author=Hollmann M, Hartley M, Heinemann S |title=Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition. |journal=Science |volume=252 |issue= 5007 |pages= 851–3 |year= 1991 |pmid= 1709304 |doi=
*cite journal | author=Rampersad V, Elliott CE, Nutt SL, "et al." |title=Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 2 |pages= 563–6 |year= 1994 |pmid= 7918660 |doi=
*cite journal | author=Rogers SW, Andrews PI, Gahring LC, "et al." |title=Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis. |journal=Science |volume=265 |issue= 5172 |pages= 648–51 |year= 1994 |pmid= 8036512 |doi=
*cite journal | author=Tomiyama M, Rodriguez-Puertas R, Cortés R, "et al." |title=Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization. |journal=Neuroscience |volume=75 |issue= 3 |pages= 901–15 |year= 1997 |pmid= 8951883 |doi=
*cite journal | author=Osten P, Srivastava S, Inman GJ, "et al." |title=The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. |journal=Neuron |volume=21 |issue= 1 |pages= 99–110 |year= 1998 |pmid= 9697855 |doi=
*cite journal | author=Srivastava S, Osten P, Vilim FS, "et al." |title=Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. |journal=Neuron |volume=21 |issue= 3 |pages= 581–91 |year= 1998 |pmid= 9768844 |doi=
*cite journal | author=Hayashi T, Umemori H, Mishina M, Yamamoto T |title=The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. |journal=Nature |volume=397 |issue= 6714 |pages= 72–6 |year= 1999 |pmid= 9892356 |doi= 10.1038/16269
*cite journal | author=Amir R, Dahle EJ, Toriolo D, Zoghbi HY |title=Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. |journal=Am. J. Med. Genet. |volume=90 |issue= 1 |pages= 69–71 |year= 2000 |pmid= 10602120 |doi=
*cite journal | author=Gécz J, Barnett S, Liu J, "et al." |title=Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation. |journal=Genomics |volume=62 |issue= 3 |pages= 356–68 |year= 2000 |pmid= 10644433 |doi= 10.1006/geno.1999.6032
*cite journal | author=Aruscavage PJ, Bass BL |title=A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing. |journal=RNA |volume=6 |issue= 2 |pages= 257–69 |year= 2000 |pmid= 10688364 |doi=
*cite journal | author=Gahring L, Carlson NG, Meyer EL, Rogers SW |title=Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation. |journal=J. Immunol. |volume=166 |issue= 3 |pages= 1433–8 |year= 2001 |pmid= 11160179 |doi=
*cite journal | author=Liu QJ, Gong YQ, Chen BX, "et al." |title= [Linkage analysis and mutation detection of GRIA3 in Smith--Fineman--Myers syndrome] |journal=Yi Chuan Xue Bao |volume=28 |issue= 11 |pages= 985–90 |year= 2001 |pmid= 11725645 |doi=
*cite journal | author=Hirbec H, Perestenko O, Nishimune A, "et al." |title=The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15221–4 |year= 2002 |pmid= 11891216 |doi= 10.1074/jbc.C200112200
*cite journal | author=Wyszynski M, Kim E, Dunah AW, "et al." |title=Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. |journal=Neuron |volume=34 |issue= 1 |pages= 39–52 |year= 2002 |pmid= 11931740 |doi=
*cite journal | author=Tomiyama M, Rodríguez-Puertas R, Cortés R, "et al." |title=Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis. |journal=Synapse |volume=45 |issue= 4 |pages= 245–9 |year= 2002 |pmid= 12125045 |doi= 10.1002/syn.10098
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ganor Y, Besser M, Ben-Zakay N, "et al." |title=Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. |journal=J. Immunol. |volume=170 |issue= 8 |pages= 4362–72 |year= 2003 |pmid= 12682273 |doi=
*cite journal | author=Flajolet M, Rakhilin S, Wang H, "et al." |title=Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 26 |pages= 16006–11 |year= 2004 |pmid= 14663150 |doi= 10.1073/pnas.2136600100
*cite journal | author=Kolleker A, Zhu JJ, Schupp BJ, "et al." |title=Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors. |journal=Neuron |volume=40 |issue= 6 |pages= 1199–212 |year= 2004 |pmid= 14687553 |doi=

External links

*

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