- Mequinol
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Mequinol 
Systematic (IUPAC) name 4-Methoxyphenol Clinical data AHFS/Drugs.com International Drug Names MedlinePlus a682437 Pregnancy cat. ? Legal status ? (CA) ? (US) Unscheduled Routes Topical Identifiers CAS number 150-76-5 
ATC code D11AX06 PubChem CID 9015 ChemSpider 8665 UNII 6HT8U7K3AM KEGG D04926 ChEMBL CHEMBL544 Synonyms 4-Hydroxyanisole; para-Guaiacol Chemical data Formula C7H8O2 Mol. mass 124.13722 g/mol - InChI=1S/C7H8O2/c1-9-7-4-2-6(8)3-5-7/h2-5,8H,1H3
Key:NWVVVBRKAWDGAB-UHFFFAOYSA-N
(what is this?) (verify)Mequinol is a drug used in combination with the drug tretinoin in the treatment of liver spots.[1] Mequinol used alone and in higher doses is used as a topical drug for medical depigmentation.
Chemistry
It is the monomethyl ether of hydroquinone, and an isomer of guaiacol.
It is often used to inhibit polymerization in monomers that polymerize with radical mechanisms, such as acrylates, methacrylates or styrene.
Uses
A combination of mequinol 2% (depigmentation agent) & tretinoin 0.01% (topical retinoid) is commonly used in treating solar lentigines (liver spots & age spots). Exactly how it works is unknown, but this compound is used along with a total skin care and sunlight avoidance program. This compound may also be used for other conditions as determined by one's dermatologist. Methoxyphenol is a depigmentation agent, like Monobenzone (benzyloxyphenol), it is the active ingredient in some depigmenting creams and ointments. A formulation of 20% 4-methoxyphenol ointment causes depigmentation in animal tissue.[2]
Lower dosages of topical mequinol and the Q-switched Ruby Laser[3] have been used to depigment normal skin in vitiligo patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo.
References
- ^ "Mequinol and Tretinoin (Topical) - MayoClinic.com". Archived from the original on 2007-08-08. http://web.archive.org/web/20070808054509/http://mayoclinic.com/health/drug-information/DR500074. Retrieved 2007-08-24.
- ^ "OCCUPATIONAL SAFETY AND HEALTH GUIDELINE FOR 4-METHOXYPHENOL". http://www.osha.gov/SLTC/healthguidelines/4-methoxyphenol/recognition.html. Retrieved 2005-10-04.
- ^ "Spectrum RD 1200 Q-switched Ruby Laser". http://www.gvlasercentre.com/laser/qruby.htm. Retrieved 2006-07-26.
Other dermatological preparations (D11) Medicated shampoos Cetrimide • Cadmium compounds • Selenium compounds • Povidone-iodine • Sulfur compounds • XenysalateOther dermatologicals Hydroquinone • Mequinol • MonobenzoneHair growth inhibitorsOtherCategories:- Phenols
- Phenol ethers
- InChI=1S/C7H8O2/c1-9-7-4-2-6(8)3-5-7/h2-5,8H,1H3
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