Tiratricol

Tiratricol

drugbox
IUPAC_name = 2- [4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]
acetic acid



CAS_number = 51-24-1
ATC_prefix = H03
ATC_suffix = AA04
ATC_supplemental = ATC|D11|AX08
PubChem = 5803
DrugBank =
C = 14 | H = 9 | I = 3 | O = 4
molecular_weight = 621.932 g/mol
synonyms = 3,3',5-triiodothyroacetic acid
TRIAC
bioavailability =
protein_bound = Presumed high
metabolism = Hepatic glucuronidation
elimination_half-life =
excretion = Biliary
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration =

Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue. It is indicated in the management of thyroid hormone resistance syndrome [cite journal |author=Carvalho GA, Ramos HE |title= [Thyroid hormone resistance syndrome] |language=Portuguese |journal=Arq Bras Endocrinol Metabol |volume=48 |issue=1 |pages=83–92 |year=2004 |pmid=15611821 |doi=/S0004-27302004000100010 PDFlink| [http://www.scielo.br/pdf/abem/v48n1/19522.pdf Free full text] |95.3 KiB ] and is used, in combination with levothyroxine, to suppress thyroid-stimulating hormone production in patients with thyroid cancer.

Tiratricol has also been widely marketed, under various trade names, as a weight loss aid. In 1999 and 2000, the United States Food and Drug Administration and Health Canada both issued warnings to the public regarding the use of dietary supplements containing tiratricol. [cite press release | url = http://www.fda.gov/bbs/topics/ANSWERS/ANS01057.html | title = FDA Warns Against Consuming Dietary Supplements Containing Tiratricol | date = November 21 2000 | accessdate = 2007-08-08 | publisher = U.S. Food and Drug Administration] [cite press release | url = http://www.hc-sc.gc.ca/ahc-asc/media/advisories-avis/1999/1999_143_e.html | title = Health Canada issues warning on products containing Tiratricol (TRIAC) | date = December 2 1999 | accessdate = 2007-08-08 | publisher = Health Canada]

Legal status

Tiratricol is not approved for sale in Canada or the United States. It was once an approved drug in Brazil, but its marketing authorization was suspended in 2003, effectively prohibiting its sale. [cite web | url = http://www.endocrino.org.br/noticia_g_exibe.php?id=9 | title = Anvisa suspende Tiratricol | language = Portuguese | date = | accessdate = 2007-08-08 | publisher = Brazilian Society of Endocrinology and Metabolism]

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • tiratricol — noun A particular kind of thyroid hormone analogue …   Wiktionary

  • ATC code D11 — ATC codes D Dermatologicals D01 Antifungals for dermatological use D02 Emollients and protectives D03 Preparations for treatment of wounds and ulcers D04 Antipruritics, including antihistamines, anesthetics, etc. D05 Antipsoriatics D06 Antibiot …   Wikipedia

  • Magnesium sulfate — Anhydrous magnesium sulfate Epsomite (heptahydrate) …   Wikipedia

  • Minoxidil — Systematic (IUPAC) name 6 …   Wikipedia

  • Perchlorate — Perchlorate …   Wikipedia

  • ATC code H03 — A section of the Anatomical Therapeutic Chemical Classification System.H Systemic hormonal preparations, excluding sex hormones and insulinsH03A Thyroid preparationsH03AA Thyroid hormones:H03AA01 Levothyroxine sodium:H03AA02 Liothyronine… …   Wikipedia

  • Potassium perchlorate — Potassium perchlorate …   Wikipedia

  • Finasteride — Finasteride …   Wikipedia

  • Cromoglicic acid — Systematic (IUPAC) name 5,5′ (2 hydroxypropane 1,3 diyl)bis(oxy)bis(4 oxo 4H chromene 2 carboxylic acid) Clinical data AHFS/ …   Wikipedia

  • Eflornithine — Systematic (IUPAC) name …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”