- Cytochrome b5 reductase
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cytochrome-b5 reductase Ribbon diagram of erythrocytic methemoglobin reductase with FAD bound. From PDB 1UMK. Identifiers EC number 1.6.2.2 CAS number 9032-25-1 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles Cytochrome-b5 reductase (also known as methemoglobin reductase) is a NADH-dependent enzyme that converts methemoglobin to hemoglobin. It contains FAD and catalyzes the reaction:
NADH + H+ + 2 ferricytochrome b5 = NAD+ + 2 ferrocytochrome b5
The following four human genes encode cytochrome-b5 reductases:
See also
External links
- MeSH Cytochrome-B(5)+Reductase
- PDB 1IB0 - crystal structure of rat CBR complexed with NAD
- PDB 1NDH - crystal structure of pig liver CBR
- PDB 1UMK - crystal structure of human erythrocyte CBR
- IPR001834 - InterPro entry for CBR
Oxidoreductases: NADH or NADPH (EC 1.6) 1.6.1: NAD/NADP 1.6.2: Heme Methemoglobin reductase · NADPH-hemoprotein reductase/Cytochrome P450 reductase · NADPH-cytochrome-c2 reductase · Leghemoglobin reductase1.6.3: Oxygen 1.6.5: Quinone or similar 1.6.6: Nitrogenous group 1.6.99: other Acetolactate synthase - Acyl CoA dehydrogenase - Apoptosis-inducing factor - Butyryl CoA dehydrogenase - Cryptochrome - Cytochrome b5 reductase - Dihydrolipoamide dehydrogenase - Flavodoxin - Methemoglobin reductase - Methylenetetrahydrofolate reductase - NADH dehydrogenase - NADPH oxidase - Nitrate reductase - Sarcosine oxidase - Thioredoxin reductaseCategories:- EC 1.6.2
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