Cytochrome b5 reductase

Cytochrome b5 reductase
cytochrome-b5 reductase
NADH cytochrome B5 reductase 1UMK.png
Ribbon diagram of erythrocytic methemoglobin reductase with FAD bound. From PDB 1UMK.
Identifiers
EC number 1.6.2.2
CAS number 9032-25-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Cytochrome-b5 reductase (also known as methemoglobin reductase) is a NADH-dependent enzyme that converts methemoglobin to hemoglobin. It contains FAD and catalyzes the reaction:

NADH + H+ + 2 ferricytochrome b5 = NAD+ + 2 ferrocytochrome b5

The following four human genes encode cytochrome-b5 reductases:

See also

External links

v · d · eOxidoreductases: NADH or NADPH (EC 1.6)
1.6.1: NAD/NADP
1.6.2: Heme
1.6.3: Oxygen
1.6.5: Quinone or similar
1.6.6: Nitrogenous group
1.6.99: other
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
v · Protein: flavoproteins

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