NADH dehydrogenase (quinone)

NADH dehydrogenase (quinone)
NADH dehydrogenase (quinone)
Identifiers
EC number 1.6.99.5
CAS number 37256-36-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a NADH dehydrogenase (quinone) (EC 1.6.99.5) is an enzyme that catalyzes the chemical reaction

NADH + H+ + acceptor \rightleftharpoons NAD+ + reduced acceptor

The 3 substrates of this enzyme are NADH, H+, and acceptor, whereas its two products are NAD+ and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADH:(quinone-acceptor) oxidoreductase. Other names in common use include reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase, NADH-quinone oxidoreductase, NADH ubiquinone oxidoreductase, DPNH-menadione reductase, D-diaphorase, and NADH2 dehydrogenase (quinone), and mitochondrial (mt) complex I. This enzyme participates in oxidative phosphorylation. Several compounds are known to inhibit this enzyme, including AMP, and 2,4-Dinitrophenol.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FUG.

References

  • Koli AK, Yearby C, Scott W, Donaldson KO (1969). "Purification and properties of three separate menadione reductases from hog liver". J. Biol. Chem. 244 (4): 621–9. PMID 4388793. 
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