NADPH dehydrogenase (quinone)

NADPH dehydrogenase (quinone)
Identifiers
EC number	1.6.99.6
CAS number	37256-37-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a NADPH dehydrogenase (quinone) (EC 1.6.99.6) is an enzyme that catalyzes the chemical reaction

NADPH + H⁺ + acceptor $\rightleftharpoons$ NADP⁺ + reduced acceptor

The 3 substrates of this enzyme are NADPH, H⁺, and acceptor, whereas its two products are NADP⁺ and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADPH:(quinone-acceptor) oxidoreductase. Other names in common use include reduced nicotinamide adenine dinucleotide phosphate (quinone), dehydrogenase, NADPH oxidase, and NADPH2 dehydrogenase (quinone). It has 2 cofactors: FAD, and Flavoprotein. Several compounds are known to inhibit this enzyme, including Folate, and Dicumarol.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1F5V.

References

• Koli AK, Yearby C, Scott W, Donaldson KO (1969). "Purification and properties of three separate menadione reductases from hog liver". J. Biol. Chem. 244 (4): 621–9. PMID 4388793. 

This EC 1.6 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Oxidoreductase stubs EC 1.6.99 NADPH-dependent enzymes Flavin enzymes Flavoprotein enzymes Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? NAD(P)H dehydrogenase (quinone) CRYAB Look at other dictionaries: NADH dehydrogenase (quinone) — Identifiers EC number 1.6.99.5 CAS number 37256 36 3 …   Wikipedia NAD(P)H dehydrogenase (quinone) — Identifiers EC number 1.6.5.2 CAS number 9032 20 6 …   Wikipedia NAD(P)H dehydrogenase (quinone 1) — NAD(P)H dehydrogenase, quinone 1 PDB rendering based on 1d4a …   Wikipedia NADPH oxidase — NADP+ The NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane bound enzyme complex. It can be found in the plasma membrane as well as in the membrane of phagosome. Contents 1 …   Wikipedia NADPH — Abbreviation for nicotinamide adenine dinucleotide phosphate (reduced form). N. cytochrome c2 reductase an enzyme catalyzing the reduction of 2ferricytochrome c2 to 2ferrocytochrome c2 at the expense of N.. SYN: cytochrome c2 reductase. N.… …   Medical dictionary quinone — 1. General name for aromatic compounds bearing two oxygens in place of two hydrogens, usually in the para position; the oxidation product of a hydroquinone. 2. SYN: 1,4 benzoquinone (1). q. reductase SYN: NADPH dehydrogenase (q.). * * * …   Medical dictionary NADH dehydrogenase — Structure of NADH dehydrogenase Identifiers EC number 1.6.5.3 …   Wikipedia Alcohol dehydrogenase — Crystallographic structure of the homodimer of human ADH5.[1] Identifiers …   Wikipedia Malate dehydrogenase — Structure of the protein with attached sugars Identifiers EC number …   Wikipedia Dihydrolipoamide dehydrogenase — PDB rendering based on 1zy8 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”