- Mark I NAAK
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The Mark I NAAK, or MARK I Kit, is United States military nomenclature for the "Nerve Agent Antidote Kit". It is a dual-chamber autoinjector: Two anti-nerve agent drugs — atropine sulfate and pralidoxime chloride — each in injectable form, constitute the kit. The kits are only effective against the nerve agents Tabun (GA), Sarin (GB), Soman (GD) and VX.
Typically, U.S. servicemembers are issued three MARK I Kits when operating in circumstances where chemical weapons are considered a potential hazard. Along with the three kits are issued one CANA (Convulsive Antidote, Nerve Agent) for simultaneous use. (CANA is the drug diazepam or Valium, an anticonvulsant.) Both of these kits are intended for use in "buddy aid" or "self aid" administration of the drugs prior to decontamination and delivery of the patient to definitive medical care.
A newer model, the ATNAA (Antidote Treatment Nerve Agent Auto-Injector),[1] has both the atropine and the pralidoxime in one syringe, allowing for simplified administration.
The use of a Mark 1 or ATNAA kit inhibits the nerve agents' purpose, thereby reducing the number of fatal casualties in the advent of chemical warfare. The kits should only be administered if nerve agents have been absorbed or inhaled.
References
- U.S. Army Medical Research Institute of Chemical Defense, Medical Management of Chemical Casualties Handbook, Third Edition (June 2000), Aberdeen Proving Ground, MD, pp 118-126.
Routes of administration / Dosage forms Oral Buccal / Sublabial / Sublingual- Mouthwash
- Toothpaste
- Ointment
- Oral spray
- Oxygen mask
- Oxygen concentrator
- Anaesthetic machine
- Relative analgesia machine
Ocular / Otologic / Nasal - Nasal spray
- Ear drops
- Eye drops
- Ointment
- Hydrogel
- Nanosphere suspension
- Mucoadhesive microdisc (microsphere tablet)
Urogenital - Ointment
- Pessary (vaginal suppository)
- Vaginal ring
- Vaginal douche
- Intrauterine device (IUD)
- Extra-amniotic infusion
- Intravesical infusion
Rectal (enteral) - Ointment
- Suppository
- Enema (Solution • Hydrogel)
- Murphy drip
- Nutrient enema
Dermal Injection / Infusion
(into tissue/blood)- Intracavernous
- Intravitreal
- Intra-articular or intrasynovial injection
- Transscleral
- Intracerebral
- Intrathecal
- Epidural
Additional explanation: Mucous membranes are used by the human body to absorb the dosage for all routes of administration, except for "Dermal" and "Injection/Infusion".
Administration routes can also be grouped as Topical (local effect) or Systemic (defined as Enteral = Digestive tract/Rectal, or Parenteral = All other routes).Routes of administration by organ system Gastrointestinal Respiratory system Pulmonary • NasalVisual system / Auditory system Ocular (Ocular-topical / Intravitreal / Transscleral) • Otologic (Oto-topical)Reproductive system Intracavernous • Intravaginal • Intrauterine (Extra-amniotic)Urinary system IntravesicalPeritoneum Central nervous system Intracerebral • Intrathecal • EpiduralCirculatory system Musculoskeletal system Skin Epicutaneous • Intradermal • SubcutaneousCategories:- Military medicine in the United States
- Nerve agents
- Antidotes
- Drug delivery devices
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