- Mesterolone
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Mesterolone 
Systematic (IUPAC) name 1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one Clinical data AHFS/Drugs.com International Drug Names Pregnancy cat. ? Legal status Prescription Only (AU) Pharmacokinetic data Metabolism Liver Identifiers CAS number 1424-00-6 
ATC code G03BB01 PubChem CID 15020 ChemSpider 14296 
UNII 0SRQ75X9I9 KEGG D04947 ChEMBL CHEMBL258918 Chemical data Formula C20H32O2 Mol. mass 304.467 g/mol SMILES eMolecules & PubChem - InChI=1S/C20H32O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h12-13,15-18,22H,4-11H2,1-3H3/t12-,13-,15-,16-,17-,18-,19-,20-/m0/s1
Key:UXYRZJKIQKRJCF-TZPFWLJSSA-N
(what is this?) (verify)Mesterolone is an orally applicable androgen, and DHT derivative. It is sold under the brand name Proviron, by Schering. In the late 70's and early 80's it was used with some success in controlled studies of men suffering from various forms of depression.
In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia, unipolar and bipolar depression. Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.[1]
Mesterolone is a relatively weak androgen and rarely used for replacement therapies.[2]
References
- ^ Kövary PM, Lenau H, Niermann H, Zierden E, Wagner H (May 1977). "Testosterone levels and gonadotrophins in Klinefelter's patients treated with injections of mesterolone cipionate". Arch Dermatol Res 258 (3): 289–94. PMID 883846. http://www.springerlink.com/content/m4374818w9337427.
- ^ Nieschlag E, Behre HM, Bouchard P, et al. (2004). "Testosterone replacement therapy: current trends and future directions". Hum. Reprod. Update 10 (5): 409–19. doi:10.1093/humupd/dmh035. PMID 15297434. http://humupd.oxfordjournals.org/cgi/content/full/10/5/409.
- Morrison, Mary Chase (2000). Hormones, Gender and the Aging Brain: The Endocrine Basis of Geriatric Psychiatry. Cambridge, UK: Cambridge University Press. p. 134. ISBN 0-521-65304-5. http://books.google.com/books?id=I7QsN6hx8IQC&pg.
- Itil TM, Michael ST, Shapiro DM, Itil KZ (June 1984). "The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study)". Methods Find Exp Clin Pharmacol 6 (6): 331–7. PMID 6431212.
Androgens (G03B) Agonist Testosterone# • Androstanolone • Fluoxymesterone • Mesterolone • Methyltestosterone • see also Anabolic steroidsSARM AC-262,356§ • Andarine (S-4)§ • BMS-564,929§ • LGD-2226§ • LGD-3303§ • Ostarine (MK-2866)§ • S-23§ • S-40503§Antiandrogen Bicalutamide • Cyproterone • Dienogest • Flutamide • Galeterone§ • MDV3100† • Nilutamide • SpironolactoneEnzyme inhibitors Alfatradiol • Bexlosteride • Dutasteride • Epristeride • Finasteride • Izonsteride • Lapisteride • TurosterideCYP17A1 inhibitorsAbiraterone • Galeterone§ • KetoconazoleCategories:- Androgens
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- Ketones
- InChI=1S/C20H32O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h12-13,15-18,22H,4-11H2,1-3H3/t12-,13-,15-,16-,17-,18-,19-,20-/m0/s1
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