Metribolone

Metribolone
Metribolone
IUPAC name
17β-17-Hydroxy-17-methyl-estra-4,9,11-trien-3-one
Other names
Methyltrienolone, R1881
Identifiers
CAS number 965-93-5 YesY
PubChem 261000
ChEMBL CHEMBL166444 YesY
Jmol-3D images Image 1
Properties
Molecular formula C19H24O2
Molar mass 284.39266
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Metribolone, (also known as methyltrienolone or R1881) is a potent, non-aromatizable androgen[1] which has also been used as a photoaffinity label for the androgen receptor.[2] It is the 17-methylated derivative of trenbolone, and is a similarly potent anabolic steroid, but with high potential for hepatotoxicity.[citation needed]

11 members of the Greek national weightlifting team and 4 Greek track and field athletes tested positive with methyltrienolone prior to the 2008 Beijing Olympic Games.[3][citation needed]

References

  1. ^ Bojar H, Maar K, Staib W (1980). "The endocrine background of human renal cell carcinoma. V. Binding of the highly potent androgen methyltrienolone (R 1881) by tumour cytosol". Urol. Int. 35 (2): 154–60. PMID 6966435. 
  2. ^ Brinkmann AO, Kuiper GG, de Boer W, Mulder E, Bolt J, van Steenbrugge GJ, van der Molen HJ (January 1986). "Characterization of androgen receptors after photoaffinity labelling with [3H]methyltrienolone (R1881)". J. Steroid Biochem. 24 (1): 245–9. doi:10.1016/0022-4731(86)90058-0. PMID 2422446. 
  3. ^ "Eleven Greek weightlifters test positive; coach suspended". Associated Press / USATODAY.com. 2008-04-04. http://www.usatoday.com/sports/olympics/2008-04-04-greek-weightlifters_N.htm. Retrieved 2009-06-28. 

External links

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Androstane (carbon 19 present)
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Estrene (carbon 19 absent)
Prohormones
1-Androstenediol • 1,4-Androstadienedione • 4-Androstenediol • 4-Androstenedione • 19-Norandrostenediol • 19-Norandrostenedione • DHEA

M: DIG

anat(t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug(A2A/2B/3/4/5/6/7/14/16), blte


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