Carbamoyl phosphate

Carbamoyl phosphate
Carbamoyl phosphate
CAS number 590-55-6
PubChem 278
MeSH Carbamoyl+phosphate
Jmol-3D images Image 1
Molecular formula CH2NO5P2-
Molar mass 141.020 g/mol
 YesY phosphate (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals it is an intermediary metabolite participating in the nitrogen disposal through in the urea cycle and the synthesis of pyrimidines.

It is produced from bicarbonate, ammonia (derived from glutamate), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:

  • HCO3 + ATP → ADP + HO–C(O)–OPO32− (carboxyl phosphate)
  • HO–C(O)–OPO32− + NH3 + OH → HPO42− + O–C(O)NH2 + H2O
  • O–C(O)NH2 + ATP → ADP + H2NC(O)OPO32−

See also


  • Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York. 

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