Carbamoyl phosphate

Carbamoyl phosphate
Carbamoyl phosphate
IUPAC name
(Carbamoyloxy)phosphonic acid
Identifiers
CAS number 590-55-6
PubChem 278
MeSH Carbamoyl+phosphate
Jmol-3D images Image 1
Properties
Molecular formula CH2NO5P2-
Molar mass 141.020 g/mol
 YesY phosphate (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals it is an intermediary metabolite participating in the nitrogen disposal through in the urea cycle and the synthesis of pyrimidines.

It is produced from bicarbonate, ammonia (derived from glutamate), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:

  • HCO3− + ATP → ADP + HO–C(O)–OPO32− (carboxyl phosphate)
  • HO–C(O)–OPO32− + NH3 + OH− → HPO42− + −O–C(O)NH2 + H2O
  • −O–C(O)NH2 + ATP → ADP + H2NC(O)OPO32−

See also

References

  • Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York. 
v · d · eNucleotide metabolic intermediates
Purine metabolism
Anabolism

R5P→IMP: R5P · PRPP · PRA · GAR · FGAR · FGAM · AIR · CAIR · SAICAR · AICAR · FAICAR

IMP→AMP: Adenylosuccinate

IMP→GMP: Xanthosine monophosphate
Catabolism
Pyrimidine metabolism
Anabolism
Catabolism

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
biochemical families: prot · nucl · carb (glpr, alco, glys) · lipd (fata/i, phld, strd, gllp, eico) · amac/i · ncbs/i · ttpy/i
v · Urea cycle Metabolic Pathway
L-citrulline Carbamoyl
phosphate		 L-ornithine
L-citrulline wpmp.png Pi Carbamoylphosphat deprotoniert.svg L-ornithine wpmp.png
Biochem reaction arrow special 3.png
L-aspartate Urea
L-aspartate wpmp.png + ATP Biochem reaction arrow special 1.png Biochem reaction arrow special 2.png Urea.png
PPi + AMP H2O
L-argino-succinate wpmp.png L-arginine wpmp.png
Biochem reaction arrow special 5.png
Fumarate wpmp.png
L-argininosuccinate Fumarate L-arginine

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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Look at other dictionaries:

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  • Carbamoyl phosphate synthetase I — Protein Name=carbamoyl phosphate synthetase 1, mitochondrial caption= Symbol=CPS1 AltSymbols= HGNCid=2323 Chromosome=2 Arm=p Band= LocusSupplementaryData= ECnumber=6.3.4.16 OMIM=608307 EntrezGene=1373 RefSeq=NM 001875 UniProt=P31327 PDB=Carbamoyl …   Wikipedia

  • Carbamoyl phosphate synthetase I deficiency — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 32671 ICD10 = ICD9 = ICD9|270.6 ICDO = OMIM = 237300 MedlinePlus = eMedicineSubj = ped eMedicineTopic = 314 MeshID = D020165 Carbamoyl phosphate synthetase I deficiency is an inherited… …   Wikipedia

  • Carbamoyl phosphate synthase II — protein Name=carbamoyl phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase caption= width= HGNCid=1424 Symbol=CAD AltSymbols= EntrezGene=790 OMIM=114010 RefSeq=NM 004341 UniProt=P27708 PDB= ECnumber= Chromosome=2 Arm=p Band=21… …   Wikipedia

  • carbamoyl phosphate synthetase — (CPS) car·bam·o·yl phos·phate syn·the·tase (CPS) (kahr bamґo əl fosґfāt sinґthə tās) 1. carbamoyl phosphate synthase (ammonia); called also carbamoyl phosphate synthetase I (CPSI). 2. carbamoyl phosphate synthase (glutamine… …   Medical dictionary

  • carbamoyl-phosphate synthase (ammonia) — car·bam·o·yl phos·phate syn·thase (am·mo·nia) (kahr bamґo əl fosґfāt sinґthās ə moґne ə) [EC 6.3.4.16] an enzyme of the ligase class that catalyzes the synthesis of carbamoyl phosphate from ammonia and carbon dioxide, the …   Medical dictionary

  • carbamoyl phosphate synthetase deficiency — car·bam·o·yl phos·phate syn·the·tase de·fi·cien·cy (kahr bamґo əl fosґfāt sinґthə tās) an autosomal recessive aminoacidopathy caused by mutations in the CPS1 gene (locus: 2q35), which encodes carbamoyl phosphate synthase… …   Medical dictionary

  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) — car·bam·o·yl phos·phate syn·thase (glu·ta·mine hy·dro·lyz·ing) (kahr bamґo əl fosґfāt sinґthās glooґtə mēn hiґdro li zing) [EC 6.3.5.5] an enzyme activity of the trifunctional CAD protein (q.v.); it is a ligase that… …   Medical dictionary

  • carbamoyl phosphate — A reactive intermediate capable of transferring its carbamoyl group to an acceptor molecule, forming citrulline from ornithine in the urea cycle, and ureidosuccinic acid from aspartic acid in …   Medical dictionary

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