Hypoxanthine

Hypoxanthine

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ImageFile=Hypoxanthin - Hypoxanthine.svg
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IUPACName=3,7-dihydropurin-6-one
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Section1= Chembox Identifiers
CASNo=68-94-0
PubChem=790
SMILES=O=C1NC=Nc2nc [nH] c12
MeSHName=Hypoxanthine
Section2= Chembox Properties
Formula=C5H4N4O
MolarMass=136.112
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Section3= Chembox Hazards
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Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It is also known as 6-Hydroxypurine. Hypoxanthine is a necessary additive in certain cell, bacteria and parasite cultures as a substrate and nitrogen source. For example it is commonly a required reagent in malaria parasite cultures since Plasmodium falciparum requires a source of hypoxanthine for nucleic acid synthesis and energy metabolism.

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It is one of the products of the action of xanthine oxidase on xanthine, though more normally in purine degradation, hypoxanthine is formed from oxidation of xanthine by xanthine oxidase.

Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotide salvage.

Hypoxanthine is also a spontaneous deamination product of adenine. Because of its resemblance to guanine, the spontaneous deamination of adenine can lead to an error in DNA transcription/replication.


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Look at other dictionaries:

  • Hypoxanthine — Général No CAS …   Wikipédia en Français

  • hypoxanthine — hypoxanthine. См. 6 оксипурин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hypoxanthine — [hī΄pōzan′thēn΄, hī΄pəzan′thēn΄, hī΄pō zan′thin, hī΄pə zan′thin] n. a nitrogenous compound, C5H4N4O, formed in the body from the breakdown of nucleic acids …   English World dictionary

  • hypoxanthine — hipoksantinas statusas T sritis chemija formulė HOC₅H₃N₄ santrumpa( os) Hyp atitikmenys: angl. hypoxanthine rus. гипоксантин ryšiai: sinonimas – 6 purinolis …   Chemijos terminų aiškinamasis žodynas

  • Hypoxanthine-guanine phosphoribosyltransferase — (HPRTcite web |url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene cmd=retrieve dopt=default list uids=3251 rn=1 |title=Entrez Gene: hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome)] ) is an enzyme in purine metabolism. PBB… …   Wikipedia

  • hypoxanthine guanine phosphoribosyltransferase — hypoxanthine guanine phosphoribosyltransferase. См. гипоксантингуанин фосфорибозилтрансфераза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hypoxanthine-guanine phosphoribosyltransferase — hy·po·xan·thine gua·nine phos·pho·ri·bo·syl·trans·fer·ase gwän .ēn .fäs fō .rī bō sil tran(t)s (.)fər .ās, .āz n an enzyme that conserves hypoxanthine in the body by limiting its conversion to uric acid and that is lacking in Lesch Nyhan syndrome …   Medical dictionary

  • hypoxanthine phosphoribosyltransferase — (HPRT) hy·po·xan·thine phos·pho·ri·bo·syl·trans·fer·ase (HPRT) (hi″po zanґthēn fos″fo ri″bo səl transґfər ās) [EC 2.4.2.8] an enzyme of the transferase class that catalyzes the phosphorylation of hypoxanthine …   Medical dictionary

  • hypoxanthine — noun Etymology: International Scientific Vocabulary Date: circa 1857 a purine base C5H4N4O found in plant and animal tissues that yields xanthine on oxidation …   New Collegiate Dictionary

  • hypoxanthine — a chemical formed in fish muscle after death; can be used as a measure of the freshness of the fish …   Dictionary of ichthyology

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