Mallory body

Mallory body
Micrograph showing a Mallory body with the characteristic twisted-rope appearance (centre of image - within a ballooning hepatocyte). H&E stain.

In histopathology, a Mallory body, Mallory-Denk body, and Mallory's hyaline, is an inclusion found in the cytoplasm of liver cells.[1]

Contents

Associated conditions

Mallory bodies are classically found in the livers of people suffering from alcoholic liver disease and were once thought to be specific for that.

They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).[2]

They are a recognized feature of Wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions.[2]

Appearance

Mallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate keratin filament proteins that have been ubiquinated, or bound by other proteins such as heat shock proteins, or p62.

Eponym

It is named for Frank Burr Mallory. [3]. [2]

See also

  • Ballooning degeneration - another histopathologic finding of steatohepatitis.

Additional images

References

  1. ^ "Cell Injury". http://library.med.utah.edu/WebPath/CINJHTML/CINJ033.html. 
  2. ^ a b c Jensen, K; Gluud, C (Oct 1994). "The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey).". Hepatology 20 (4 Pt 1): 1061–77. doi:10.1002/hep.1840200440. PMID 7927209. 
  3. ^ Template:AKADrewParlin

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