Nifuratel

Nifuratel

Systematic (IUPAC) name
5-[(methylthio)methyl]-3-{[(1E)-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	4936-47-4
ATC code	G01AX05
PubChem	CID 6433427
UNII	U60U6P08SP Y
KEGG	D01050 Y
Chemical data
Formula	C10H11N3O5S
Mol. mass	285.28 g/mol
Y(what is this?)  (verify)

Nifuratel is a drug used in gynecology. It is a local antiprotozoal and antifungal agent that may also be given orally.

Nifuratel appears to have a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections from Candida spp.^[1]

Taken orally, or as a vaginal pessary, it is used in the treatment of a wide range of infections of the genito-urinary tract, especially if there is no accurate diagnosis available. For example it may be used in the treatment of women exhibiting vaginal discharge where there is uncertainty as to whether the cause is Trichomonas vaginalis or Candida strains such as Candida albicans.

Side effects appear to be minimal or non-existent and it has a safe toxicological profile.^[2]

References

1. ^ Treatment of candidal urinary tract infection with nifuratel. R N Grüneberg, A Leakey
2. ^ Microbiological and pharmaco-toxicological profile of nifuratel and its favourable risk/benefit ratio for the treatment of vulvo-vaginal infections. A review. Werner Mendling, Federico Mailland Klinik für Frauenheilkunde und Geburtshilfe, Klinikum Am Urban, Berlin, Germany.