- Diiodohydroxyquinoline
-
Diiodohydroxyquinoline 
5,7-diiodoquinolin-8-olIdentifiers CAS number 83-73-8 
PubChem 3728 KEGG D00581 MeSH Iodoquinol ChEMBL CHEMBL86754 
Jmol-3D images Image 1 - C1=CC2=C(C(=C(C=C2I)I)O)N=C1
Properties Molecular formula C9H5I2NO Molar mass 396.951 
(verify) (what is: 
/
?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)Infobox references Diiodohydroxyquinoline (INN) or iodoquinol (USAN), widely known by the trade name Diodoquin, is a quinoline derivative which can be used in the treatment of amoebiasis.[1]
Iodoquinol is poorly absorbed from the gastrointestinal tract and is amebicidal at the site of infection.[2] It acts by chelating ferrous ions essential for metabolism.[3]
In the United States this medicine is sold under the names Diquinol, Yodoquinol, and Yodoxin.[4] Yodoxin is available in 210- and 650-mg oral tablet form.[5]
Susceptibility of Dientamoeba fragilis has been measured.[6]
References
- ^ Ghaskadbi S, Vaidya VG (March 1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline". Mutat. Res. 222 (3): 219–22. doi:10.1016/0165-1218(89)90137-7. PMID 2493578.
- ^ http://www.drugs.com/mmx/iodoquinol.html
- ^ http://web.gideononline.com/web/therapy/index.php?type=drugs&code=20130&view=General
- ^ http://www.drugs.com/cons/yodoxin.html
- ^ http://www.walgreens.com/library/finddrug/druginfo.html?particularDrug=Yodoxin&searchChar=Y
- ^ Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F (May 1994). "Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole". Antimicrob. Agents Chemother. 38 (5): 1157–60. PMC 188168. PMID 8067755. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=8067755.
Antiparasitics – antiprotozoal agents – agents against amoebozoa/amebicide (P01) Entamoeba Nitroimidazole derivativesOtherHydroxyquinoline derivativesCl (Chlorquinaldol) • Br (Tilbroquinol, Broxyquinoline) • I (Diiodohydroxyquinoline) • I,Cl (Clioquinol)
related: ChiniofonDichloroacetamide derivativesOther/ungroupedarsenic (Arsthinol, Difetarsone, Glycobiarsol) • phenanthroline (Phanquinone) • aminoacridine (Mepacrine) • quinazoline (Trimetrexate) • thiazole (Tenonitrozole) • sesquiterpene (Fumagillin)Acanthamoeba Antiparasitics – antiprotozoal agents – Excavata antiparasitics (P01) Discicristata TrypanosomiasisAfrican trypanosomiasis: ornithine (Eflornithine#) • arsenical (Melarsoprol#) • benzamidine (Pentamidine#) • naphthalenesulfonate (Suramin#)
Chagas disease: nitroimidazole (Benznidazole#) • nitrofuran (Nifurtimox#)Trichozoa nitroimidazole (Metronidazole#, Tinidazole) • benzimidazole (Albendazole)
thiazole (Nitazoxanide) • nitrofuran (Furazolidone)
aminoacridine (Quinacrine)Trichomoniasisnitroimidazole (Metronidazole, Secnidazole)
oxyquinoline (Iodoquinol) • tetracycline (Doxycycline) • neomycin (Paromomycin)Categories:- Organoiodides
- Quinolinols
- Biochemistry stubs
Wikimedia Foundation. 2010.
