Fumagillin

Fumagillin

drugbox


IUPAC_name = (2"E",4"E",6"E",8"E")-10-{ [(3"S",4"S",5"S",6"R")-
5-methoxy-4- [2-methyl-3-(3-methylbut-2-enyl)
oxiran-2-yl] -1-oxaspiro [2.5] octan-6-yl] oxy}-
10-oxo-deca-2,4,6,8-tetraenoic acid
CAS_number = 23110-15-8
ATC_prefix = P01
ATC_suffix = AX10
ATC_supplemental =
PubChem = 6436022
DrugBank = EXPT01509
C=26 | H=36 | O=7
molecular_weight = 460.566 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
pregnancy_category =
legal_status =
routes_of_administration =

Fumagillin is an antibiotic originally used against fungal "Nosema apis" infections in honeybees. Some studies found it to be effective against some myxozoan parasites, including "Myxobolus cerebralis," an important parasite of fish; however, in the more rigorous tests required for U.S. Food and Drug Administration approval, it was ineffective. Fumagillin can block blood vessel formation by binding to an enzyme called methionine aminopeptidase 2. [cite journal
url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14533670&dopt=Abstract
author=Gilbert, M. A. & Granath, W.O. Jr.
year=2003
title=Whirling disease and salmonid fish: life cycle, biology, and disease
journal=Journal of Parasitology
volume=89
issue=4
pages=pp. 658–667
doi=10.1645/GE-82R]

There are reports that Fumagillin might play a role in controlling Nosema ceranae, which has recently been hypothesized as a possible cause of Colony Collapse Disorder. [cite news
url=http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2007/04/26/MNGK7PFOMS1.DTL
title=UCSF scientist tracks down suspect in honeybee deaths
author=Sabin Russell
date=2007-04-26
publisher=San Francisco Chronicle
language=English] [cite news
url=http://sev.prnewswire.com/agriculture/20070425/NEW13725042007-1.html
title=Scientists Identify Pathogens That May Be Causing Global Honeybee Deaths
author=
date=2007-04-25
publisher=PR Newswire
language=English]

References


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