Fumagillin

Fumagillin

drugbox


IUPAC_name = (2"E",4"E",6"E",8"E")-10-{ [(3"S",4"S",5"S",6"R")-
5-methoxy-4- [2-methyl-3-(3-methylbut-2-enyl)
oxiran-2-yl] -1-oxaspiro [2.5] octan-6-yl] oxy}-
10-oxo-deca-2,4,6,8-tetraenoic acid
CAS_number = 23110-15-8
ATC_prefix = P01
ATC_suffix = AX10
ATC_supplemental =
PubChem = 6436022
DrugBank = EXPT01509
C=26 | H=36 | O=7
molecular_weight = 460.566 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
pregnancy_category =
legal_status =
routes_of_administration =

Fumagillin is an antibiotic originally used against fungal "Nosema apis" infections in honeybees. Some studies found it to be effective against some myxozoan parasites, including "Myxobolus cerebralis," an important parasite of fish; however, in the more rigorous tests required for U.S. Food and Drug Administration approval, it was ineffective. Fumagillin can block blood vessel formation by binding to an enzyme called methionine aminopeptidase 2. [cite journal
url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14533670&dopt=Abstract
author=Gilbert, M. A. & Granath, W.O. Jr.
year=2003
title=Whirling disease and salmonid fish: life cycle, biology, and disease
journal=Journal of Parasitology
volume=89
issue=4
pages=pp. 658–667
doi=10.1645/GE-82R]

There are reports that Fumagillin might play a role in controlling Nosema ceranae, which has recently been hypothesized as a possible cause of Colony Collapse Disorder. [cite news
url=http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2007/04/26/MNGK7PFOMS1.DTL
title=UCSF scientist tracks down suspect in honeybee deaths
author=Sabin Russell
date=2007-04-26
publisher=San Francisco Chronicle
language=English] [cite news
url=http://sev.prnewswire.com/agriculture/20070425/NEW13725042007-1.html
title=Scientists Identify Pathogens That May Be Causing Global Honeybee Deaths
author=
date=2007-04-25
publisher=PR Newswire
language=English]

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Fumagillin — Strukturformel Allgemeines Freiname Fumagillin …   Deutsch Wikipedia

  • fumagillin — Naturally secreted antibiotic from Aspergillus fumigatus that inhibits endothelial cell proliferation and is therefore potentially anti angiogenic …   Dictionary of molecular biology

  • fumagillin — fu·ma·gil·lin .fyü mə jil ən n a crystalline orally effective antibiotic ester of an unsaturated acid produced by a soil fungus of the genus Aspergillus (A. fumigatus) and used in the treatment of amebiasis …   Medical dictionary

  • fumagillin — fu·ma·gil·lin …   English syllables

  • fumagillin — ˌfyüməˈjilə̇n noun ( s) Etymology: fumagill (rearrangement of some of the letters of the species name New Latin Aspergillus fumigatus, from Aspergillus, genus name + fumigatus, specific epithet, from Latin, past participle of fumigare to… …   Useful english dictionary

  • METAP2 — Methionyl aminopeptidase 2, also known as METAP2, is a human gene. PBB Summary section title = summary text = This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein… …   Wikipedia

  • Colony collapse disorder — Honey bees entering a beehive Colony collapse disorder (CCD) is a phenomenon in which worker bees from a beehive or European honey bee colony abruptly disappear. While such disappearances have occurred throughout the history of apiculture, the… …   Wikipedia

  • Nosema ceranae — Scientific classification Kingdom: Fungi Phylum: Zygomycota Class: Dihaplophasea Micros …   Wikipedia

  • beekeeping — /bee kee ping/, n. the rearing and breeding of honeybees; apiculture. [1830 40; BEE1 + KEEPING] * * * or apiculture Care and manipulation of honeybees to enable them to produce and store more honey than they need so that the excess can be… …   Universalium

  • Myxobolus cerebralis — Triactinomyxon stage of Myxobolus cerebralis. Note the three tails . Scientific classification …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”