Normoblast

An erythroblast is a type of red blood cell which still retains a cell nucleus. It is the immediate precursor of a normal erythrocyte.

Nomenclature

The term normoblast is sometimes used as a synonym for erythroblast, but at other times it is considered a subcategory. In the latter context, there are two types of erythroblasts:

• "normoblasts" - develop as expected
• "megaloblasts" - unusually large erythroblasts that can be associated with pernicious anemia and folic acid deficiency (collectively called megaloblastic anemia)

Development

There are four stages in the development of a normoblast.

HSC=Hematopoietic stem cell , Progenitor=Progenitor cell , L-blast=lymphoblast , Lymphocyte , Mo-blast=Monoblast , Monocyte , Myeloblast , Pro-M=Promyelocyte , Myelocyte , Meta-M=Metamyelocyte , Neutrophil , Eosinophil , Basophil , Pro-E=Proerythroblast , Baso-E=Basophilic erythroblast , poly-E=Polychromatic erythroblast , Ortho-E=orthochromatic erythroblast , Erythrocyte , Promegakaryocyte , megakaryocyte , Platlet

Illustration	Description	Image
	Pronormoblast
	Basophilic normoblast
	Polychromatic normoblast (also polychromatophilic)
	Orthochromatic normoblast (also orthochromatophilic)

Additional images

• 

  Hematopoiesis

See also

• Erythropoiesis
• Hemopoiesis
• Pluripotential hemopoietic stem cell

External links

• MeSH Normoblasts
• Histology at BU 01804loa - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
• Histology at uiowa.edu