Megaloblast

A megaloblast is an unusually large erythroblast that can be associated with pernicious anemia (Vitamin B₁₂ deficiency) and folic acid deficiency (collectively called megaloblastic anemia). It is differentiated from a normoblast, which is a normally-sized erythroblast. This kind of anemia leads to macrocytes (abnormally large red cells). The cause of this cellular gigantism is an impairment in DNA synthesis which delays nuclear maturation and cell division. Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony.

Additional images

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  Blood cell lineage

• 

  Hematopoiesis

See also

• Erythropoiesis
• Hemopoiesis
• Pluripotential hemopoietic stem cell

External links

• Pronormoblasts Presented by the University of Virginia
• Basophilic Normoblasts Presented by the University of Virginia
• Polychromatophilic Normoblasts Presented by the University of Virginia
• Orthochromatic Normoblasts Presented by the University of Virginia
• "Megaloblast" at Dorland's Medical Dictionary

• "Normoblast" at Dorland's Medical Dictionary

• "Erythroblast" at Dorland's Medical Dictionary

• normoblast at eMedicine Dictionary
• MeSH Normoblasts
• Histology at BU 01804loa - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
• Histology at uiowa.edu

This medical sign article is a stub. You can help Wikipedia by expanding it.v · Categories: Blood cells Medical sign stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Marion County Courthouse (Ohio) Fingask railway station Look at other dictionaries: megaloblast — MEGALOBLÁST, megaloblaste, s.n. (biol.) Globulă roşie cu nucleul anormal mărit, caracteristică în anemia pernicioasă; (rar) macroblast. – Din fr. mégaloblaste, engl. megaloblast. Trimis de claudia, 13.09.2007. Sursa: DEX 98  megaloblást s. n.,… …   Dicționar Român megaloblast — noun Date: 1890 a large erythroblast that appears in the blood especially in pernicious anemia • megaloblastic adjective …   New Collegiate Dictionary megaloblast — megaloblastic, adj. /meg euh leuh blast /, n. Pathol. an abnormally large, immature, and dysfunctional red blood cell found in the blood of persons with pernicious anemia or certain other disorders. [1895 1900; MEGALO + BLAST] * * * …   Universalium megaloblast — noun An abnormally large red blood cell associated with pernicious anemia and with folic acid deficiency …   Wiktionary megaloblast — A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblasts four stages of development are as follows: 1) …   Medical dictionary Megaloblast — Als Megaloblasten werden ungewöhnlich große, kern und hämoglobinhaltige Vorläuferzellen der Erythrozyten im Knochenmark bezeichnet. Sie entwickeln sich aus dem noch hämoglobinfreien Promegaloblasten. Die reifen, vergrößerten Erythrozyten werden… …   Deutsch Wikipedia Megaloblast — Me|ga|lo|blạst, der; en, en <meist Pl.> [zu griech. mégas (megal ) = groß u. blastós = Keim] (Med.): abnorm große, kernhaltige Vorstufe der roten Blutkörperchen …   Universal-Lexikon megaloblast — me|ga|lo|blast Mot Agut Nom masculí …   Diccionari Català-Català Megaloblast — Me|ga|lo|blạst 〈m.; Gen.: en, Pl.: en; meist Pl.; Med.〉 abnorm große Vorstufe der roten Blutkörperchen [Etym.: <Megalo… + …blast] …   Lexikalische Deutsches Wörterbuch Megaloblast — Megalo|blạst [↑mega... u. ↑...blast] m; en, en (meist Mehrz.): abnorm große, kernhaltige Vorstufe der roten Blutkörperchen …   Das Wörterbuch medizinischer Fachausdrücke 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”