Nebulette

Nebulette
nebulette
Identifiers
Symbol NEBL
Entrez 10529
HUGO 16932
OMIM 605491
RefSeq NM_006393
UniProt O76041
Other data
Locus Chr. 10 p12

Nebulette is an isoform of the protein nebulin. While nebulin (600-900 kDa) is expressed preferentially in skeletal muscle, nebulette (107 kDa) is expressed in cardiac muscle. Nebulette was identified in 1995 by Moncman and Wang using primary cultures of chicken embryonic cardiomyocytes by immunoprecipitations with certain anti-nebulin monoclonal antibodies.[1] Normal expression of nebulette is essential for the assembly and contractile function of myofibrils.[2]

References

  1. ^ Moncman & Wang; Wang, K (1995). "Nebulette: a 107 kD nebulin-like protein in cardiac muscle". Cell Motil Cytoskeleton 32 (3): 205–25. doi:10.1002/cm.970320305. PMID 8581976. 
  2. ^ Moncman & Wang; Wang, K (2002). "Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function". Exp Cell Res 273 (2): 204–18. doi:10.1006/excr.2001.5423. PMID 11822876. 

External links

v · d · eHistology: muscle tissue (TH H2.00.05, H3.3)
Smooth
muscle
Striated
muscle
Costamere/
DAPC
Membrane/
extracellular
Intracellular

Dystrophin · Dystrobrevin (A, B) · Syntrophin (A, B1, B2, G1, G2) · Syncoilin · Dysbindin · Synemin/desmuslin

related: NOS1 · Caveolin 3
Sarcomere/
(a, i, and h bands;
z and m lines)
General
Myocardium · Intercalated disc · Nebulette
Both
Fiber
Cells
Other
Desmin · Sarcoplasm · Sarcolemma (T-tubule) · Sarcoplasmic reticulum
Other/
ungrouped

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

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