Nebulette

Nebulette
nebulette
Identifiers
Symbol NEBL
Entrez 10529
HUGO 16932
OMIM 605491
RefSeq NM_006393
UniProt O76041
Other data
Locus Chr. 10 p12

Nebulette is an isoform of the protein nebulin. While nebulin (600-900 kDa) is expressed preferentially in skeletal muscle, nebulette (107 kDa) is expressed in cardiac muscle. Nebulette was identified in 1995 by Moncman and Wang using primary cultures of chicken embryonic cardiomyocytes by immunoprecipitations with certain anti-nebulin monoclonal antibodies.[1] Normal expression of nebulette is essential for the assembly and contractile function of myofibrils.[2]

References

  1. ^ Moncman & Wang; Wang, K (1995). "Nebulette: a 107 kD nebulin-like protein in cardiac muscle". Cell Motil Cytoskeleton 32 (3): 205–25. doi:10.1002/cm.970320305. PMID 8581976. 
  2. ^ Moncman & Wang; Wang, K (2002). "Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function". Exp Cell Res 273 (2): 204–18. doi:10.1006/excr.2001.5423. PMID 11822876. 

External links

v · d · eHistology: muscle tissue (TH H2.00.05, H3.3)
Smooth
muscle
Striated
muscle
Costamere/
DAPC
Membrane/
extracellular
Intracellular

Dystrophin · Dystrobrevin (A, B) · Syntrophin (A, B1, B2, G1, G2) · Syncoilin · Dysbindin · Synemin/desmuslin

related: NOS1 · Caveolin 3
Sarcomere/
(a, i, and h bands;
z and m lines)
General
Myocardium · Intercalated disc · Nebulette
Both
Fiber
Cells
Other
Desmin · Sarcoplasm · Sarcolemma (T-tubule) · Sarcoplasmic reticulum
Other/
ungrouped

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Nebulin — Solution structure of the SH3 domain from human nebulin.[1] Identifiers Symbol …   Wikipedia

  • Histology — Not to be confused with Historiography. A stained histologic specimen, sandwiched between a glass microscope slide and coverslip, mounted on the stage of a light microscope …   Wikipedia

  • Myofibril — 1. Axon 2. Neuromuscular junction 3. Muscle fiber 4. Myofibril Latin myofibrilla MeSH …   Wikipedia

  • Sarcomere — A band redirects here. For other uses, see A band. Sarcomere Image of sarcomere Latin sarcomerum Code TH …   Wikipedia

  • Motor unit — ”A motor unit is a single α motor neuron and all of the corresponding muscle fibers it innervates; all of these fibers will be of the same type (either fast twitch or slow twitch). When a motor unit is activated, all of its fibers contract.… …   Wikipedia

  • Cardiac muscle — Dog Cardiac Muscl …   Wikipedia

  • Actin — G Actin (PDB code: 1j6z). ADP and the divalent cation are highlighted …   Wikipedia

  • Myosin — Part of the myosin II structure. Atoms in the heavy chain are colored red on the left hand side, and atoms in the light chains are colored orange and yellow. Myosins comprise a family of ATP dependent motor proteins and are best known for their… …   Wikipedia

  • Muscle spindle — Latin fusus neuromuscularis Code TH H3.11.06.0.00018 Muscle spindles are sensory receptors within the belly of a muscle, which primarily detect changes in the length of this muscle. They convey length information to the central nervous system via …   Wikipedia

  • Myocyte — A myocyte (also known as a muscle cell)[1] is the type of cell found in muscles. They arise from myoblasts.[2] Each myocyte contains myofibrils, which are long, long chains of sarcomeres, the contractile units of the cell. There are various… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”