Sarcoglycan

Sarcoglycan

The sarcoglcyans are a family of five transmembrane proteins (α, β, γ, δ or ε) involved in the protein complex responsible for connecting the muscle fibre cytoskeleton to the extracellular matrix, preventing damage the muscle fibre sarcolemma through shearing forces.

Mutations in the α, β, γ or δ genes (not ε) encoding these proteins can lead to the associated limb-girdle muscular dystrophy.

Genes

* SGCA
* SGCB
* SGCC
* SGCD
* SGCE
* SGCG
* SGCZ


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  • sarcoglycan — (= adhalin) Complex of a, b and g sarcoglycans. a sarcoglycan (50DAG, A2, adhalin), b sarcoglycan (43DAG; A3b) and g sarcoglycan (35DAG; A4) are all transmembrane glycoproteins that associate with dystroglycan in the sarcolemma (approximate… …   Dictionary of molecular biology

  • sarcoglycan — noun Any of a family of transmembrane proteins involved in the protein complex responsible for connecting the muscle fibre cytoskeleton to the extracellular matrix, preventing damage to the muscle fibre sarcolemma through shearing forces …   Wiktionary

  • sarcoglycan — sar·co·gly·can (sahr″ko gliґkan) any of a family of transmembrane glycoproteins of the sarcolemma, constituting a subcomplex of the dystrophin glycoprotein complex that associates with dystrophin and mediates muscle membrane stability. It… …   Medical dictionary

  • SGCB — Sarcoglycan, beta (43kDa dystrophin associated glycoprotein), also known as SGCB, is a human gene.cite web | title = Entrez Gene: SGCB sarcoglycan, beta (43kDa dystrophin associated glycoprotein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db …   Wikipedia

  • SGCD — Sarcoglycan, delta (35kDa dystrophin associated glycoprotein), also known as SGCD, is a human gene.cite web | title = Entrez Gene: SGCD sarcoglycan, delta (35kDa dystrophin associated glycoprotein)| url =… …   Wikipedia

  • SGCE — Sarcoglycan, epsilon, also known as SGCE, is a human gene.cite web | title = Entrez Gene: SGCE sarcoglycan, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=8910| accessdate = ] PBB Summary section… …   Wikipedia

  • SGCG — Sarcoglycan, gamma (35kDa dystrophin associated glycoprotein), also known as SGCG, is a human gene.cite web | title = Entrez Gene: SGCG sarcoglycan, gamma (35kDa dystrophin associated glycoprotein)| url =… …   Wikipedia

  • SGCA — Sarcoglycan, alpha (50kDa dystrophin associated glycoprotein), also known as SGCA, is a human gene.cite web | title = Entrez Gene: SGCA sarcoglycan, alpha (50kDa dystrophin associated glycoprotein)| url =… …   Wikipedia

  • Mesoangioblast — A mesoangioblast is a mesenchymal like cell, associated with the walls of the large vessels. Mesoangioblasts exhibit many similarities to pericytes found in the small vessels. Mesoangioblasts are relatively undifferentiated cells with the… …   Wikipedia

  • DTNA — Dystrobrevin, alpha Identifiers Symbols DTNA; D18S892E; DRP3; DTN; DTN A; FLJ96209; LVNC1 External IDs …   Wikipedia

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