- Sarcospan
protein
Name = sarcospan
caption =
width =
HGNCid = 11322
Symbol = SSPN
AltSymbols =
EntrezGene = 8082
OMIM = 601599
RefSeq =
UniProt =
PDB =
ECnumber =
Chromosome = 12
Arm = p
Band = 11.2
LocusSupplementaryData =Sarcospan, discovered by the research group of Kevin Campbell, is a 25-kDa
transmembrane protein located in thedystrophin-associated protein complex ofskeletal muscle cells. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly.cite journal |author=Crosbie et al |title=Sarcospan, the 25-kDa transmembrane component of the dystrophin-glycoprotein complex |journal=J Biol Chem |volume=272 |issue=50 |pages=31221–4 |year=1997 |pmid=9395445 |doi=10.1074/jbc.272.50.31221 ] Loss of sarcospan expression occurs in patients withDuchenne muscular dystrophy , indicating thatdystrophin is required for proper localization of sarcospan. Interestingly, sarcospanknockout mice exhibit normal muscle structure and function, indicating that sarcospan is not necessary for muscle to develop.cite journal |author=Lebakken et al |title=Sarcospan-deficient mice maintain normal muscle function. |journal=Mol Cell Biol |volume=20 |issue=5 |pages=1669–77 |year=2000 |pmid=10669744 |doi=10.1128/MCB.20.5.1669-1677.2000 ]References
External links
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