ABCC4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Identifiers
Symbols	ABCC4; EST170205; MOAT-B; MOATB; MRP4
External IDs	OMIM: 605250 MGI: 2443111 HomoloGene: 74563 GeneCards: ABCC4 Gene
Gene Ontology Molecular function • nucleotide binding • chloride channel activity • ATP binding • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism • 15-hydroxyprostaglandin dehydrogenase (NAD+) activity • ATPase activity • ATPase activity, coupled to transmembrane movement of substances Cellular component • membrane fraction • plasma membrane • integral to membrane • platelet dense granule membrane • platelet dense granule membrane Biological process • platelet degranulation • ion transport • blood coagulation • biological_process • platelet activation • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10257	239273
Ensembl	ENSG00000125257	ENSMUSG00000032849
UniProt	O15439	Q3TZN9
RefSeq (mRNA)	NM_001105515.1	NM_001033336
RefSeq (protein)	NP_001098985.1	NP_001028508
Location (UCSC)	Chr 13: 95.67 – 95.95 Mb	Chr 14: 118.88 – 119.11 Mb
PubMed search	[1]	[2]

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.^[1][2]

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.^[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. ^[4]

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Fluorouracil (5-FU) Activity edit

See also

• ATP-binding cassette transporter

References

1. ^ "Entrez Gene: ATP-binding cassette". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10257. 
2. ^ Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD (July 1998). "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter". Cancer Res. 58 (13): 2741–7. PMID 9661885. 
3. ^ Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS (August 2008). "Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation". J. Clin. Invest. 118 (8): 2747–57. doi:10.1172/JCI35067. PMC 2467383. PMID 18636120. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2467383. 
4. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". http://www.wikipathways.org/index.php/Pathway:WP1601. 

Further reading

• Guey LT, García-Closas M, Murta-Nascimento C, et al. (2010). "Genetic susceptibility to distinct bladder cancer subphenotypes.". Eur. Urol. 57 (2): 283–92. doi:10.1016/j.eururo.2009.08.001. PMID 19692168. 
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896464. 
• Rodríguez-Návoa S, Labarga P, Soriano V, et al. (2009). "Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study". Clin. Infect. Dis. 48 (11): e108–16. doi:10.1086/598507. PMID 19400747. 
• Holmes MV, Shah T, Vickery C, et al. (2009). Luo, Yuan. ed. "Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies". PLoS ONE 4 (12): e7960. doi:10.1371/journal.pone.0007960. PMC 2778625. PMID 19956635. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2778625. 
• Knauer MJ, Urquhart BL, Meyer zu Schwabedissen HE, et al. (2010). "Human skeletal muscle drug transporters determine local exposure and toxicity of statins". Circ. Res. 106 (2): 297–306. doi:10.1161/CIRCRESAHA.109.203596. PMID 19940267. 
• Jedlitschky G, Cattaneo M, Lubenow LE, et al. (2010). "Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: evidence from patients with delta-storage pool deficiencies". Am. J. Pathol. 176 (3): 1097–103. doi:10.2353/ajpath.2010.090425. PMC 2832132. PMID 20133816. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2832132. 
• Saito A, Kawamoto M, Kamatani N (2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". J. Hum. Genet. 54 (6): 317–23. doi:10.1038/jhg.2009.31. PMID 19343046. 
• Hosgood HD, Menashe I, He X, et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respir Med 103 (12): 1866–70. doi:10.1016/j.rmed.2009.06.016. PMC 2783799. PMID 19625176. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2783799. 
• Ban H, Andoh A, Imaeda H, et al. (2010). "The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease". Journal of gastroenterology 45 (10): HASH(0x1e0d7f0). doi:10.1007/s00535-010-0248-y. PMID 20393862. 
• Kucka M, Kretschmannova K, Murano T, et al. (2010). "Dependence of multidrug resistance protein-mediated cyclic nucleotide efflux on the background sodium conductance". Mol. Pharmacol. 77 (2): 270–9. doi:10.1124/mol.109.059386. PMC 2812068. PMID 19903828. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2812068. 
• Aleksunes LM, Yeager RL, Klaassen CD (2009). "Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers". Xenobiotica 39 (7): 514–22. doi:10.1080/00498250902952514. PMC 2698955. PMID 19480556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2698955. 
• Ming X, Thakker DR (2010). "Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil". Biochem. Pharmacol. 79 (3): 455–62. doi:10.1016/j.bcp.2009.08.029. PMID 19735648. 
• Brüggemann M, Trautmann H, Hoelzer D, et al. (2009). "Multidrug resistance-associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia". Blood 114 (26): 5400–1; author reply 5401–2. doi:10.1182/blood-2009-09-243741. PMID 20018925. 
• Clemente MI, Alvarez S, Serramía MJ, et al. (2009). "Non-steroidal anti-inflammatory drugs increase the antiretroviral activity of nucleoside reverse transcriptase inhibitors in HIV type-1-infected T-lymphocytes: role of multidrug resistance protein 4". Antivir. Ther. (Lond.) 14 (8): 1101–11. doi:10.3851/IMP1468. PMID 20032540. 
• Radilova H, Libra A, Holasova S, et al. (2009). "COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells". Mol. Cell. Biochem. 330 (1–2): 131–40. doi:10.1007/s11010-009-0126-1. PMID 19399588. 
• Low SK, Kiyotani K, Mushiroda T, et al. (2009). "Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients". J. Hum. Genet. 54 (10): 564–71. doi:10.1038/jhg.2009.79. PMID 19696793. 
• Ansari M, Sauty G, Labuda M, et al. (2009). "Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia". Blood 114 (7): 1383–6. doi:10.1182/blood-2008-11-191098. PMID 19515727. 
• Yuasa I, Umetsu K, Matsusue A, et al. (2010). "A Japanese-specific allele in the GALNT11 gene". Leg Med (Tokyo) 12 (4): 208–11. doi:10.1016/j.legalmed.2010.04.001. PMID 20547088. 
• Moyer AM, Sun Z, Batzler AJ, et al. (2010). "Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy". Cancer Epidemiol. Biomarkers Prev. 19 (3): 811–21. doi:10.1158/1055-9965.EPI-09-0871. PMC 2837367. PMID 20200426. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2837367. 
• Xu S, Weerachayaphorn J, Cai SY, et al. (2010). "Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression". Am. J. Physiol. Gastrointest. Liver Physiol. 299 (1): G126–35. doi:10.1152/ajpgi.00522.2010. PMC 2904108. PMID 20395535. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2904108. 

External links

• MeSH ABCC4+protein,+human

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