Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), also known as TAP1, is a human gene.

section_title =
summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [cite web | title = Entrez Gene: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6890| accessdate = ]

ee also

* ATP-binding cassette transporter


Further reading

citations =
*cite journal | author=Townsend A, Trowsdale J |title=The transporters associated with antigen presentation. |journal=Semin. Cell Biol. |volume=4 |issue= 1 |pages= 53–61 |year= 1993 |pmid= 8453065 |doi=
*cite journal | author=Schölz C, Tampé R |title=The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms. |journal=J. Bioenerg. Biomembr. |volume=37 |issue= 6 |pages= 509–15 |year= 2006 |pmid= 16691491 |doi= 10.1007/s10863-005-9500-1
*cite journal | author=Beck S, Kelly A, Radley E, "et al." |title=DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. |journal=J. Mol. Biol. |volume=228 |issue= 2 |pages= 433–41 |year= 1992 |pmid= 1453454 |doi=
*cite journal | author=Bodmer JG, Marsh SG, Albert ED, "et al." |title=Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. |journal=Tissue Antigens |volume=39 |issue= 4 |pages= 161–73 |year= 1992 |pmid= 1529427 |doi=
*cite journal | author=Colonna M, Bresnahan M, Bahram S, "et al." |title=Allelic variants of the human putative peptide transporter involved in antigen processing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 3932–6 |year= 1992 |pmid= 1570316 |doi=
*cite journal | author=Bahram S, Arnold D, Bresnahan M, "et al." |title=Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 22 |pages= 10094–8 |year= 1991 |pmid= 1946428 |doi=
*cite journal | author=Trowsdale J, Hanson I, Mockridge I, "et al." |title=Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. |journal=Nature |volume=348 |issue= 6303 |pages= 741–4 |year= 1991 |pmid= 2259383 |doi= 10.1038/348741a0
*cite journal | author=Spies T, Bresnahan M, Bahram S, "et al." |title=A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. |journal=Nature |volume=348 |issue= 6303 |pages= 744–7 |year= 1991 |pmid= 2259384 |doi= 10.1038/348744a0
*cite journal | author=Cerundolo V, Alexander J, Anderson K, "et al." |title=Presentation of viral antigen controlled by a gene in the major histocompatibility complex. |journal=Nature |volume=345 |issue= 6274 |pages= 449–52 |year= 1990 |pmid= 2342577 |doi= 10.1038/345449a0
*cite journal | author=Szafer F, Oksenberg JR, Steinman L |title=New allelic polymorphisms in TAP genes. |journal=Immunogenetics |volume=39 |issue= 5 |pages= 374 |year= 1994 |pmid= 8168860 |doi=
*cite journal | author=Jackson DG, Capra JD |title=TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11079–83 |year= 1994 |pmid= 8248212 |doi=
*cite journal | author=Glynne R, Kerr LA, Mockridge I, "et al." |title=The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing. |journal=Eur. J. Immunol. |volume=23 |issue= 4 |pages= 860–6 |year= 1993 |pmid= 8458375 |doi=
*cite journal | author=Beck S, Abdulla S, Alderton RP, "et al." |title=Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. |journal=J. Mol. Biol. |volume=255 |issue= 1 |pages= 1–13 |year= 1996 |pmid= 8568858 |doi= 10.1006/jmbi.1996.0001
*cite journal | author=Chen HL, Gabrilovich D, Tampé R, "et al." |title=A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer. |journal=Nat. Genet. |volume=13 |issue= 2 |pages= 210–3 |year= 1996 |pmid= 8640228 |doi= 10.1038/ng0696-210
*cite journal | author=Ahn K, Meyer TH, Uebel S, "et al." |title=Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. |journal=EMBO J. |volume=15 |issue= 13 |pages= 3247–55 |year= 1996 |pmid= 8670825 |doi=
*cite journal | author=Lewis JW, Neisig A, Neefjes J, Elliott T |title=Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP. |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 873–83 |year= 1997 |pmid= 8805302 |doi=
*cite journal | author=Nijenhuis M, Hämmerling GJ |title=Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site. |journal=J. Immunol. |volume=157 |issue= 12 |pages= 5467–77 |year= 1997 |pmid= 8955196 |doi=
*cite journal | author=Gobin SJ, Wilson L, Keijsers V, Van den Elsen PJ |title=Antigen processing and presentation by human trophoblast-derived cell lines. |journal=J. Immunol. |volume=158 |issue= 8 |pages= 3587–92 |year= 1997 |pmid= 9103419 |doi=
*cite journal | author=Ahn K, Gruhler A, Galocha B, "et al." |title=The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. |journal=Immunity |volume=6 |issue= 5 |pages= 613–21 |year= 1997 |pmid= 9175839 |doi=

External links


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