ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5, also known as ABCC5, is a human gene.cite web | title = Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10057| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.cite web | title = Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10057| accessdate = ]

ee also

* ATP-binding cassette transporter

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Allikmets R, Gerrard B, Hutchinson A, Dean M |title=Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. |journal=Hum. Mol. Genet. |volume=5 |issue= 10 |pages= 1649–55 |year= 1997 |pmid= 8894702 |doi=
*cite journal | author=Kool M, de Haas M, Scheffer GL, "et al." |title=Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. |journal=Cancer Res. |volume=57 |issue= 16 |pages= 3537–47 |year= 1997 |pmid= 9270026 |doi=
*cite journal | author=Suzuki T, Nishio K, Sasaki H, "et al." |title=cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line. |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 3 |pages= 790–4 |year= 1997 |pmid= 9325169 |doi= 10.1006/bbrc.1997.7346
*cite journal | author=Belinsky MG, Bain LJ, Balsara BB, "et al." |title=Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. |journal=J. Natl. Cancer Inst. |volume=90 |issue= 22 |pages= 1735–41 |year= 1998 |pmid= 9827529 |doi=
*cite journal | author=Cole SP |title=Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. |journal=J. Natl. Cancer Inst. |volume=91 |issue= 10 |pages= 888–9 |year= 1999 |pmid= 10340910 |doi=
*cite journal | author=McAleer MA, Breen MA, White NL, Matthews N |title=pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23541–8 |year= 1999 |pmid= 10438534 |doi=
*cite journal | author=Suzuki T, Sasaki H, Kuh HJ, "et al." |title=Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts. |journal=Gene |volume=242 |issue= 1-2 |pages= 167–73 |year= 2000 |pmid= 10721709 |doi=
*cite journal | author=Oguri T, Isobe T, Suzuki T, "et al." |title=Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer. |journal=Int. J. Cancer |volume=86 |issue= 1 |pages= 95–100 |year= 2000 |pmid= 10728601 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Wijnholds J, Mol CA, van Deemter L, "et al." |title=Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7476–81 |year= 2000 |pmid= 10840050 |doi= 10.1073/pnas.120159197
*cite journal | author=Jedlitschky G, Burchell B, Keppler D |title=The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30069–74 |year= 2000 |pmid= 10893247 |doi= 10.1074/jbc.M005463200
*cite journal | author=Alcorn J, Lu X, Moscow JA, McNamara PJ |title=Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. |journal=J. Pharmacol. Exp. Ther. |volume=303 |issue= 2 |pages= 487–96 |year= 2002 |pmid= 12388627 |doi= 10.1124/jpet.102.038315
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wielinga PR, van der Heijden I, Reid G, "et al." |title=Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17664–71 |year= 2003 |pmid= 12637526 |doi= 10.1074/jbc.M212723200
*cite journal | author=Pascolo L, Fernetti C, Pirulli D, "et al." |title=Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 1 |pages= 259–65 |year= 2003 |pmid= 12646196 |doi=
*cite journal | author=Reid G, Wielinga P, Zelcer N, "et al." |title=Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1094–103 |year= 2003 |pmid= 12695538 |doi=
*cite journal | author=Dazert P, Meissner K, Vogelgesang S, "et al." |title=Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart. |journal=Am. J. Pathol. |volume=163 |issue= 4 |pages= 1567–77 |year= 2003 |pmid= 14507663 |doi=
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Jedlitschky G, Tirschmann K, Lubenow LE, "et al." |title=The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. |journal=Blood |volume=104 |issue= 12 |pages= 3603–10 |year= 2004 |pmid= 15297306 |doi= 10.1182/blood-2003-12-4330
*cite journal | author=Meyer Zu Schwabedissen HE, Grube M, Heydrich B, "et al." |title=Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. |journal=Am. J. Pathol. |volume=166 |issue= 1 |pages= 39–48 |year= 2005 |pmid= 15631998 |doi=

External links

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