Transmembrane domain of ABC transporters

Transmembrane domain of ABC transporters

Symbol = ABC_membrane
Name = ABC transporter transmembrane region

width =
caption =
Pfam= PF00664
InterPro= IPR001140
SCOP = 1pf4
TCDB = 3.A.1
OPM family= 18
OPM protein= 1pf4

ABC transporter transmembrane domain is main transmembrane structural unit of ATP-binding cassette transporter which consist of six transmembrane domaines. Many members of the ABC transporter family (Pfam|PF00005) have two such regions.cite journal |author=Kerr ID |title=Structure and association of ATP-binding cassette transporter nucleotide-binding domains |journal=Biochim. Biophys. Acta |volume=1561 |issue=1 |pages=- |year=2002 |pmid=11988180] .cite journal |author=Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K |title=Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter |journal=Structure |volume=9 |issue=7 |pages=- |year=2001 |pmid=11470432] cite journal |author=Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ |title=The crystal structure of the MJ0796ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter |journal=J. Biol. Chem. |volume=276 |issue=34 |pages=- |year=2001 |pmid=11402022] cite journal |author=Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF |title=Crystal structure of the ATP-binding subunit of an ABC transporter |journal=Nature |volume=396 |issue=6712 |pages=703–707 |year=1998 |pmid=9872322 |doi=10.1038/25393] cite journal |author=Welte W, Breed J, Boos W, Diederichs K, Vonrhein C, Muller C, Diez J, Greller G, Schnell C |title=Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis |journal=EMBO J. |volume=19 |issue=22 |pages=- |year=2000 |pmid=11080142 |doi=10.1093/emboj/19.22.5951] cite journal |author=Wiley DC, Gaudet R |title=Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing|journal=EMBO J. |volume=20 |issue=17 |pages=- |year=2001 |pmid=11532960 |doi=10.1093/emboj/20.17.4964]

Human proteins containing this domain

TAP1; TAP2; TAPL; ara;


External links

* [ ABC transporter integral membrane type-1 domain] in PROSITE

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