ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3, also known as ABCC3, is a human gene.cite web | title = Entrez Gene: ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8714| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.cite web | title = Entrez Gene: ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8714| accessdate = ]

ee also

* ATP-binding cassette transporter

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Allikmets R, Gerrard B, Hutchinson A, Dean M |title=Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. |journal=Hum. Mol. Genet. |volume=5 |issue= 10 |pages= 1649–55 |year= 1997 |pmid= 8894702 |doi=
*cite journal | author=Kool M, de Haas M, Scheffer GL, "et al." |title=Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. |journal=Cancer Res. |volume=57 |issue= 16 |pages= 3537–47 |year= 1997 |pmid= 9270026 |doi=
*cite journal | author=Kiuchi Y, Suzuki H, Hirohashi T, "et al." |title=cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). |journal=FEBS Lett. |volume=433 |issue= 1-2 |pages= 149–52 |year= 1998 |pmid= 9738950 |doi=
*cite journal | author=Uchiumi T, Hinoshita E, Haga S, "et al." |title=Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 103–10 |year= 1998 |pmid= 9813153 |doi=
*cite journal | author=Belinsky MG, Bain LJ, Balsara BB, "et al." |title=Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. |journal=J. Natl. Cancer Inst. |volume=90 |issue= 22 |pages= 1735–41 |year= 1998 |pmid= 9827529 |doi=
*cite journal | author=Fromm MF, Leake B, Roden DM, "et al." |title=Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants. |journal=Biochim. Biophys. Acta |volume=1415 |issue= 2 |pages= 369–74 |year= 1999 |pmid= 9889399 |doi=
*cite journal | author=König J, Rost D, Cui Y, Keppler D |title=Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. |journal=Hepatology |volume=29 |issue= 4 |pages= 1156–63 |year= 1999 |pmid= 10094960 |doi= 10.1002/hep.510290404
*cite journal | author=Cole SP |title=Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. |journal=J. Natl. Cancer Inst. |volume=91 |issue= 10 |pages= 888–9 |year= 1999 |pmid= 10340910 |doi=
*cite journal | author=Kool M, van der Linden M, de Haas M, "et al." |title=MRP3, an organic anion transporter able to transport anti-cancer drugs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6914–9 |year= 1999 |pmid= 10359813 |doi=
*cite journal | author=Ortiz DF, Li S, Iyer R, "et al." |title=MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte. |journal=Am. J. Physiol. |volume=276 |issue= 6 Pt 1 |pages= G1493–500 |year= 1999 |pmid= 10362653 |doi=
*cite journal | author=Takada T, Suzuki H, Sugiyama Y |title=Characterization of 5'-flanking region of human MRP3. |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 3 |pages= 728–32 |year= 2000 |pmid= 10772892 |doi= 10.1006/bbrc.2000.2507
*cite journal | author=Nies AT, König J, Pfannschmidt M, "et al." |title=Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. |journal=Int. J. Cancer |volume=94 |issue= 4 |pages= 492–9 |year= 2002 |pmid= 11745434 |doi=
*cite journal | author=Tatebe S, Sinicrope FA, Kuo MT |title=Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 5 |pages= 1427–33 |year= 2002 |pmid= 11820781 |doi= 10.1006/bbrc.2002.6367
*cite journal | author=Scheffer GL, Kool M, de Haas M, "et al." |title=Tissue distribution and induction of human multidrug resistant protein 3. |journal=Lab. Invest. |volume=82 |issue= 2 |pages= 193–201 |year= 2002 |pmid= 11850532 |doi=
*cite journal | author=Zelcer N, Saeki T, Bot I, "et al." |title=Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. |journal=Biochem. J. |volume=369 |issue= Pt 1 |pages= 23–30 |year= 2003 |pmid= 12220224 |doi= 10.1042/BJ20021081
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hooijberg JH, Peters GJ, Assaraf YG, "et al." |title=The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis. |journal=Biochem. Pharmacol. |volume=65 |issue= 5 |pages= 765–71 |year= 2003 |pmid= 12628490 |doi=
*cite journal | author=Bodo A, Bakos E, Szeri F, "et al." |title=Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23529–37 |year= 2003 |pmid= 12704183 |doi= 10.1074/jbc.M303515200
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Lang T, Hitzl M, Burk O, "et al." |title=Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver. |journal=Pharmacogenetics |volume=14 |issue= 3 |pages= 155–64 |year= 2004 |pmid= 15167703 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes