ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11, also known as ABCC11, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, an SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.cite web | title = Entrez Gene: ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85320| accessdate = ]

ee also

* ATP-binding cassette transporter

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dean M, Rzhetsky A, Allikmets R |title=The human ATP-binding cassette (ABC) transporter superfamily. |journal=Genome Res. |volume=11 |issue= 7 |pages= 1156–66 |year= 2001 |pmid= 11435397 |doi= 10.1101/gr.184901 | doi_brokendate=2008-10-03
*cite journal | author=Tammur J, Prades C, Arnould I, "et al." |title=Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. |journal=Gene |volume=273 |issue= 1 |pages= 89–96 |year= 2001 |pmid= 11483364 |doi=10.1016/S0378-1119(01)00572-8
*cite journal | author=Bera TK, Lee S, Salvatore G, "et al." |title=MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. |journal=Mol. Med. |volume=7 |issue= 8 |pages= 509–16 |year= 2002 |pmid= 11591886 |doi=
*cite journal | author=Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T |title=Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 933–9 |year= 2001 |pmid= 11688999 |doi= 10.1006/bbrc.2001.5865
*cite journal | author=Lai L, Tan TM |title=Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 497–503 |year= 2002 |pmid= 11802779 |doi=10.1042/0264-6021:3610497
*cite journal | author=Stríz I, Jaresová M, Lácha J, "et al." |title=MRP 8/14 and procalcitonin serum levels in organ transplantations. |journal=Ann. Transplant. |volume=6 |issue= 2 |pages= 6–9 |year= 2002 |pmid= 11803621 |doi=
*cite journal | author=Tomita H, Yamada K, Ghadami M, "et al." |title=Mapping of the wet/dry earwax locus to the pericentromeric region of chromosome 16. |journal=Lancet |volume=359 |issue= 9322 |pages= 2000–2 |year= 2002 |pmid= 12076558 |doi=10.1016/S0140-6736(02)08835-9
*cite journal | author=Turriziani O, Schuetz JD, Focher F, "et al." |title=Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11. |journal=Biochem. J. |volume=368 |issue= Pt 1 |pages= 325–32 |year= 2002 |pmid= 12133003 |doi= 10.1042/BJ20020494
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Guo Y, Kotova E, Chen ZS, "et al." |title=MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 29509–14 |year= 2003 |pmid= 12764137 |doi= 10.1074/jbc. M304059200
*cite journal | author=Bouma G, Lam-Tse WK, Wierenga-Wolf AF, "et al." |title=Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin. |journal=Diabetes |volume=53 |issue= 8 |pages= 1979–86 |year= 2004 |pmid= 15277376 |doi=10.2337/diabetes.53.8.1979
*cite journal | author=Vogl T, Ludwig S, Goebeler M, "et al." |title=MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. |journal=Blood |volume=104 |issue= 13 |pages= 4260–8 |year= 2005 |pmid= 15331440 |doi= 10.1182/blood-2004-02-0446
*cite journal | author=Chen ZS, Guo Y, Belinsky MG, "et al." |title=Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). |journal=Mol. Pharmacol. |volume=67 |issue= 2 |pages= 545–57 |year= 2005 |pmid= 15537867 |doi= 10.1124/mol.104.007138
*cite journal | author=Bortfeld M, Rius M, König J, "et al." |title=Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system. |journal=Neuroscience |volume=137 |issue= 4 |pages= 1247–57 |year= 2006 |pmid= 16359813 |doi= 10.1016/j.neuroscience.2005.10.025
*cite journal | author=Yoshiura K, Kinoshita A, Ishida T, "et al." |title=A SNP in the ABCC11 gene is the determinant of human earwax type. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 324–30 |year= 2006 |pmid= 16444273 |doi= 10.1038/ng1733
*cite journal | author=Viemann D, Barczyk K, Vogl T, "et al." |title=MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program. |journal=Blood |volume=109 |issue= 6 |pages= 2453–60 |year= 2007 |pmid= 17095618 |doi= 10.1182/blood-2006-08-040444

External links

*

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