EIF2A

Eukaryotic translation initiation factor 2A, 65kDa, also known as EIF2A, is a human gene.

PBB_Summary
section_title =
summary_text = EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002). [supplied by OMIM] cite web | title = Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Merrick WC |title=Mechanism and regulation of eukaryotic protein synthesis. |journal=Microbiol. Rev. |volume=56 |issue= 2 |pages= 291–315 |year= 1992 |pmid= 1620067 |doi=
*cite journal | author=Zoll WL, Horton LE, Komar AA, "et al." |title=Characterization of mammalian eIF2A and identification of the yeast homolog. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37079–87 |year= 2002 |pmid= 12133843 |doi= 10.1074/jbc.M207109200
*cite journal | author=Koumenis C, Naczki C, Koritzinsky M, "et al." |title=Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. |journal=Mol. Cell. Biol. |volume=22 |issue= 21 |pages= 7405–16 |year= 2002 |pmid= 12370288 |doi=10.1128/MCB.22.21.7405-7416.2002
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Page AB, Owen CR, Kumar R, "et al." |title=Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia. |journal=Acta Neuropathol. |volume=106 |issue= 1 |pages= 8–16 |year= 2003 |pmid= 12687390 |doi= 10.1007/s00401-003-0693-2
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ito T, Marintchev A, Wagner G |title=Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. |journal=Structure |volume=12 |issue= 9 |pages= 1693–704 |year= 2005 |pmid= 15341733 |doi= 10.1016/j.str.2004.07.010
*cite journal | author=Weiser DC, Sikes S, Li S, Shenolikar S |title=The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 48904–14 |year= 2005 |pmid= 15345721 |doi= 10.1074/jbc.M404416200
*cite journal | author=Komar AA, Gross SR, Barth-Baus D, "et al." |title=Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 15601–11 |year= 2005 |pmid= 15718232 |doi= 10.1074/jbc.M413728200
*cite journal | author=Wang J, Laschinger C, Zhao XH, "et al." |title=Mechanical force activates eIF-2alpha phospho-kinases in fibroblast. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 1 |pages= 123–30 |year= 2005 |pmid= 15781241 |doi= 10.1016/j.bbrc.2005.02.140
*cite journal | author=Gorrini C, Loreni F, Gandin V, "et al." |title=Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 26 |pages= 9200–5 |year= 2005 |pmid= 15961545 |doi= 10.1073/pnas.0409513102
*cite journal | author=Su Q, Wang S, Baltzis D, "et al." |title=Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 1 |pages= 63–8 |year= 2006 |pmid= 16373505 |doi= 10.1073/pnas.0508207103
*cite journal | author=Squatrito M, Mancino M, Sala L, Draetta GF |title=Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 3 |pages= 859–68 |year= 2006 |pmid= 16631606 |doi= 10.1016/j.bbrc.2006.03.205
*cite journal | author=Scheuner D, Patel R, Wang F, "et al." |title=Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. |journal=J. Biol. Chem. |volume=281 |issue= 30 |pages= 21458–68 |year= 2006 |pmid= 16717090 |doi= 10.1074/jbc.M603784200
*cite journal | author=Mazroui R, Sukarieh R, Bordeleau ME, "et al." |title=Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4212–9 |year= 2007 |pmid= 16870703 |doi= 10.1091/mbc.E06-04-0318
*cite journal | author=Fribley AM, Evenchik B, Zeng Q, "et al." |title=Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 31440–7 |year= 2006 |pmid= 16928686 |doi= 10.1074/jbc.M604356200
*cite journal | author=Fritsch RM, Schneider G, Saur D, "et al." |title=Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation. |journal=J. Biol. Chem. |volume=282 |issue= 31 |pages= 22551–62 |year= 2007 |pmid= 17553788 |doi= 10.1074/jbc.M702673200
*cite journal | author=Nayak R, Pintel DJ |title=Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA. |journal=J. Virol. |volume=81 |issue= 21 |pages= 11908–16 |year= 2007 |pmid= 17715234 |doi= 10.1128/JVI.01132-07

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