ABCC12

ATP-binding cassette, sub-family C (CFTR/MRP), member 12, also known as ABCC12, is a human gene.cite web | title = Entrez Gene: ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94160| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.cite web | title = Entrez Gene: ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94160| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Haimeur A, Conseil G, Deeley RG, Cole SP |title=The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. |journal=Curr. Drug Metab. |volume=5 |issue= 1 |pages= 21-53 |year= 2004 |pmid= 14965249 |doi=
*cite journal | author=Dean M, Rzhetsky A, Allikmets R |title=The human ATP-binding cassette (ABC) transporter superfamily. |journal=Genome Res. |volume=11 |issue= 7 |pages= 1156-66 |year= 2001 |pmid= 11435397 |doi= 10.1101/gr.184901
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bera TK, Iavarone C, Kumar V, "et al." |title=MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6997-7002 |year= 2002 |pmid= 12011458 |doi= 10.1073/pnas.102187299
*cite journal | author=Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T |title=Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 933-9 |year= 2001 |pmid= 11688999 |doi= 10.1006/bbrc.2001.5865
*cite journal | author=Tammur J, Prades C, Arnould I, "et al." |title=Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. |journal=Gene |volume=273 |issue= 1 |pages= 89-96 |year= 2001 |pmid= 11483364 |doi=

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