In a biological cell, a melanosome is an organelle containing melanin, the most common light-absorbing pigment found in the animal kingdom.

Cells that synthesize melanins are called melanocytes, and also the retinal pigment epithelium cells, whereas cells that have merely engulfed the melanosomes are called melanophages.



Melanosomes are bound by a lipid membrane and are, in general, rounded, sausage-like, or cigar-like in shape. The shape is constant for a given species and cell type.

They have a characteristic ultrastructure on electron microscopy, which varies according to the maturity of the melanosome, and, for research purposes, a numeric staging system is sometimes used.

Synthesis of melanin

They are dependent for their pigment on a set of enzymes within the cell (especially tyrosinase) that synthesise the large polymers generically known as melanin.

Before it contains much pigment (sufficient to be seen on light microscopy), it is known as a pre-melanosome.

Dysfunction or absence of the melanin-synthesising enzymes leads to various patterns of albinism.


In some melanocytes, the melanosomes remain static within the cell. In other types of melanocyte, the cell can extend its surface as long pseudopodia, carrying melanosomes away from the center of the cell and increasing the cell's effectiveness in absorbing light.

This happens slowly in dermal melanocytes in response to ultraviolet light, as well as production of new melanosomes and increased 'donation' of melanosomes to adjacent keratinocytes, the normal skin surface cells. This donation comes about because some keratinocytes may engulf the end of the melanocyte pseudopodia, which contain many melanosomes. Cytoplasmic dynein will carry the vesicles containing the melanin to the center of the cell. This causes melanosomes to become sequestered around the keratinocyte's nucleus, providing optimal protection from UV rays.

These changes, together, are responsible for tanning after exposure to UV or sunlight.

In animals

In many species of fish, amphibians, crustaceans, and reptiles, melanosomes can be highly mobile within the cell in response to hormonal (or sometimes neural) control, and this leads to visible changes in colour that are used for behavioural signaling. Melanosomes found in certain fish species contain pigments that control the color of the fish's scales. Molecular motors, when signaled, will either carry melanosomes containing pigments out to the periphery of the cell, or concentrate them at the center. The motors responsible for concentrating the melanosomes at the center are dynein, which move the melanosomes along microtubule tracts towards the minus end (i.e. the center of the cell). The motors responsible for dispersing the melanosomes to the periphery are kinesin, which are plus end directed motors. Since the plus end of microtubules are oriented towards the periphery, kinesin will carry melanosomes to the periphery. Dispersion of melanosomes to the periphery causes the cell to appear darker. Concentration of melanosomes towards the center will cause the cell to appear lighter color. This is how a protective system works for the fish on a molecular level.

The beautiful and rapid colour changes seen in many cephalopods (octopuses and squid) are based, however, on a different system, the chromatophore organ.

In fossils

Recent (2008) discoveries by Xu Xing, a Chinese paleontologist, have found fossilized feathers in rock formations dating from the Jurassic period (200 to 150 million years ago) to the late Tertiary period (65 to 2 million years ago). The feathers contain preserved residues of carbon that were previously thought to be traces of bacteria that decomposed feather tissues but are in fact microscopic organic imprints of fossilized melanosomes. Some of these structures still maintain an iridescent color typical of feather and fur tissues. It is conjectured that these microscopic structures could be further studied to reveal the original colors and textures of softer tissues in fossils. "The discovery of ultra-structural detail in feather fossils opens up remarkable possibilities for the investigation of other features in soft-bodied fossils, like fur and even internal organs," said Derek Briggs of the Yale University study team.[1][2]

Melanosomes were used to discover the true colors of fossil Anchiornis huxleyi by the Beijing Museum of Natural History.[3][4]


Melanosomes are believed to template melanin polymerization by way of amyloidogenesis of the protein Pmel17, which is present in abundant quantities in melanosomes.[5]


  1. ^ Andrea Thompson (2008-07-08). "Feather Fossils Could Yield Dinosaur Colors". LiveScience. Retrieved 2009-08-29. 
  2. ^ "Ancient Bird Feathers Had Iridescent Glow". Fox News. 2009-08-26.,2933,542981,00.html. Retrieved 2009-08-28. 
  3. ^ Li, Q., Gao, K.-Q., Vinther, J., Shawkey, M.D., Clarke, J.A., D'Alba, L., Meng, Q., Briggs, D.E.G. and Prum, R.O. "Plumage color patterns of an extinct dinosaur." Science, 327(5971): 1369 - 1372. doi:10.1126/science.1186290 PMID 20133521
  4. ^ The Real Colors of a Dinosaur Revealed for the First Time.
  5. ^ Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, et al. 2005 Functional Amyloid Formation within Mammalian Tissue. PLoS Biol 4(1): e6. doi:10.1371/journal.pbio.0040006

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  • melanosome — melanosome. См. меланосома. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • melanosome — [mel′ə nō sōm΄, mə lan′əsōm] n. an organelle of a cell containing densely packed melanin pigments along rows of tiny fibers …   English World dictionary

  • Mélanosome — Le mélanosome est un organite intracellulaire, parent des lysosomes et des granules des plaquettes sanguines, à l intérieur duquel sont fabriquées les mélanines, pigments protégeant la peau des radiations solaires dans le règne animal. Il est… …   Wikipédia en Français

  • Melanosome (geology) — A melanosome in geology refers to the dark, mafic mineral bands formed in migmatite which is undergoing eutaxitic melting; probably to form granite. These form bands with leucosomes and such a texture may be described as schlieren or migmatitic.… …   Wikipedia

  • melanosome — noun Date: 1940 a melanin producing granule in a melanocyte …   New Collegiate Dictionary

  • melanosome — Membrane bounded organelle found in melanocytes; when melanin synthesis is active internal structure is characteristic, containing melanofilaments that have a periodicity of around 9nm and are arranged in parallel arrays. Mature melanosomes, in… …   Dictionary of molecular biology

  • melanosome — /meuh lan euh sohm , mel euh neuh /, n. Cell Biol. an organelle in melanocytes that synthesizes and stores melanin. [1935 40; MELANO + SOME3] * * * …   Universalium

  • melanosome — noun Any organelle that contains melanin …   Wiktionary

  • melanosome — The generally oval pigment granule (0.2 by 0.6 μm) produced by melanocytes. SYN: eumelanosome. [melano + G. soma, body] giant m. a large spherical m. (1 to 6 μ in diameter) formed in the cytoplasm of melanocytes in café au lait spots and other… …   Medical dictionary

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