Organ of Zuckerkandl

Organ of Zuckerkandl
The abdominal aorta and its branches. (Organ of Zuckerkandl is not shown, but it usually appears alongside the abdominal aorta.)

The Organ of Zuckerkandl is a chromaffin body derived from neural crest located at the bifurcation of the aorta or at the origin of the inferior mesenteric artery. It can be the source of pheochromocytoma.^[1]

The term "paraaortic bodies" is also sometimes used to describe it, as it usually arises near the abdominal aorta, but this term can be the source of confusion, because the term "corpora paraaortica" is also used to describe the aortic body, which arises near the thoracic aorta.

Function

Its physiological role is thought to be of greatest importance during the early gestational period as a homeostatic regulator of blood pressure, secreting catecholamines into the fetal circulation.

The organ itself regresses in the late third trimester and following birth to form the aorticosympathetic group of the adult paraganglia.

Pathology

It can be the source of paraganglioma.^[2]

The Organ of Zuckerkandl is of pathological significance in the adult as a common extra-adrenal site of pheochromocytoma though the most common extra-adrenal site is in the superior para-aortic region between the diaphragm and lower renal poles. ^[3]

Extra-adrenal tumors account for around 10% of all cases of pheochromocytoma.^[4] Resection has been described.^[5]

In addition to its endocrine effects, it can also cause obstructive pathology.^[6]

Eponym

This diffuse group of neuroendocrine sympathetic fibres was first described by Emil Zuckerkandl, a professor of anatomy at the University of Vienna, in 1901.^[7]

Nomenclature

Some sources equate the "aortic bodies" and "paraaortic bodies",^[8] while other sources explicitly distinguish between the two.^[9][10] When a distinction is made, the "aortic bodies" are chemoreceptors which regulate circulation, while the "paraaortic bodies" are the chromaffin cells which manufacture catecholamines.

References

1. ^ Dossett LA, Rudzinski ER, Blevins LS, Chambers EP (September 2007). "Malignant pheochromocytoma of the organ of Zuckerkandl requiring aortic and vena caval reconstruction". Endocr Pract 13 (5): 493–7. PMID 17872352. http://aace.metapress.com/openurl.asp?genre=article&issn=1530-891X&volume=13&issue=5&spage=493. 
2. ^ Saurborn DP, Kruskal JB, Stillman IE, Parangi S (2003). "Best cases from the AFIP: paraganglioma of the organs of Zuckerkandl". Radiographics 23 (5): 1279–86. doi:10.1148/rg.235035022. PMID 12975514. http://radiographics.rsnajnls.org/cgi/pmidlookup?view=long&pmid=12975514. 
3. ^ Whalen RK, Althausen AF, Daniels GH. Extra-adrenal pheochromocytoma. J Urol. 1992 Jan;147(1):1-10. Review. PubMed PMID: 1729490
4. ^ http://content.nejm.org/cgi/content/extract/346/19/1486
5. ^ Kravarusic D, Pinto-Rojas A, Al-Assiri A, Sigalet D (October 2007). "Laparoscopic resection of extra-adrenal pheochromocytoma--case report and review of the literature in pediatric patients". J. Pediatr. Surg. 42 (10): 1780–4. doi:10.1016/j.jpedsurg.2007.06.025. PMID 17923216. http://linkinghub.elsevier.com/retrieve/pii/S0022-3468(07)00443-5. 
6. ^ Blecha M, Galanopolous C, Dharkar D, Salti G (September 2005). "Massive organ of Zuckerkandl inducing small bowel obstruction". J. Am. Coll. Surg. 201 (3): 480–1. doi:10.1016/j.jamcollsurg.2005.02.031. PMID 16125084. http://linkinghub.elsevier.com/retrieve/pii/S1072-7515(05)00257-7. 
7. ^ synd/3111 at Who Named It?
8. ^ "organs of Zuckerkandl" at Dorland's Medical Dictionary
9. ^ MeSH Aortic+Bodies
10. ^ MeSH Para-Aortic+Bodies

External links

• 00520 at CHORUS
• paraaortic+bodies at eMedicine Dictionary

This anatomy article is a stub. You can help Wikipedia by expanding it.v · Categories: Angiology Anatomy stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Roman Catholicism in Uzbekistan Nitro (comics) Look at other dictionaries: Zuckerkandl — is a surname that may refer to:* Berta Zuckerkandl (1864 1945), Austrian journalist, author * Emil Zuckerkandl (1849 1910), Austrian Hungarian anatomist ** Organ of Zuckerkandl, para aortic catecholamine secreting body * Emile Zuckerkandl (born… …   Wikipedia Zuckerkandl — ist der Name mehrerer Personen Berta Zuckerkandl (1864–1945), österreichgebürtige Journalistin und Autorin Emil Zuckerkandl (1849–1910), österreichischer Mediziner Emile Zuckerkandl (* 1922), österreichgebürtiger Biologe und Physiologe Otto… …   Deutsch Wikipedia Zuckerkandl-Organ — Paraganglion der Gallenblase Paraganglien sind Ganglien, also Ansammlungen von Nervenzellkörpern, mit teilweise endokriner Funktion. Sie stehen funktionell zwischen vegetativem Nerven und endokrinem System und entstehen aus Zellen, die embryonal… …   Deutsch Wikipedia Zuckerkandl-Organ — Zụckerkandl Organ [nach dem dt. Anatomen Richard Zuckerkandl, 1849 1910]: netzartig angeordnete Gruppen chromaffiner Zellen am Ursprung der unteren Gekröseschlagader …   Das Wörterbuch medizinischer Fachausdrücke Zuckerkandl — Zụckerkandl,   Emil Richard, österreichischer Pathologe, * Raab 18. 9. 1849, ✝ Wien 28. 5. 1910; 1879 82 Professor in Wien, dann in Graz, ab 1888 wieder in Wien. Zuckerkandl beschäftigte sich besonders mit der Anatomie des Kopfes. Er entdeckte… …   Universal-Lexikon organ — Any part of the body exercising a specific function, as of respiration, secretion, or digestion. SYN: organum [TA], organon. [L. organum, fr. G. organon, a tool, instrument] accessory organs 1. SYN …   Medical dictionary Zuckerkandl — Emil, Austrian anatomist, 1849–1910. See Z. bodies, under body, Z. convolution, Z. fascia, organs of Z., under organ …   Medical dictionary Emil Zuckerkandl — (* 18. September 1849 in Győr; † 28. Mai 1910 in Wien) war ein österreichisch ungarischer Anatom und physischer Anthropologe. Nach ihm sind das Zuckerkandl Organ und die Zuckerkandl Faszie (Bindege …   Deutsch Wikipedia Órgano de Zuckerkandl — The abdominal aorta and its branches. (Organ of Zuckerkand is not shown, but it usually appears alongside the abdominal aorta.) El Órgano de Zuckerkandl son los cúmulos de tejido neuroendocrino, localizado en el área toracoabdominal posterior y… …   Wikipedia Español body — 1. The head, neck, trunk, and extremities. The human b., consisting of head (caput), neck (collum), trunk (truncus), and limbs (membra). 2. The material part of a human, as distinguished from the …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”