Dipalmitoylphosphatidylcholine

Dipalmitoylphosphatidylcholine
Dipalmitoylphosphatidylcholine
Identifiers
CAS number 2644-64-6 YesY
PubChem 6138
ChemSpider 398235 YesY
UNII 2W15RT5V7V YesY
Jmol-3D images Image 1
Properties
Molecular formula C40H80NO8P
Molar mass 734.039 g/mol
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Dipalmitoylphosphatidylcholine (DpPC) is a phospholipid (and a lecithin) consisting of two palmitic acids and is the major constituent of pulmonary surfactant. It is also the only surface active component of lung surfactant capable of lowering surface tension to near zero levels. DpPC is synthesized mainly through remodeling of phosphatidylcholine. It is thought that a lysophosphatidylcholine (lysoPC) acyltransferase may play a critical role in its synthesis. The identity of this acyltransferase has not yet been confirmed.[1] Dipalmitoylphosphatidylcholine is an exception to the rule of thumb that biological phospholipids are synthesized with a saturated fat at the R1 position and an unsaturated fat at the R2 position.

It is also used for research purposes in studying liposomes, lipid bilayers, and model biological membranes and in the formation of reconstituted HDL (rHDL) particles.

See also

References



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