Phosphatidylinositol 4-phosphate
- Phosphatidylinositol 4-phosphate
Phosphatidylinositol 4-phosphate (PtdIns4"P") is a precursor of Phosphatidylinositol (4,5)-bisphosphate. PtdIns4"P" is prevalent in the membrane of the Golgi apparatus.
In the Golgi apparatus, PtdIns4"P" binds to the GTP-binding protein ARF and to effector proteins, including four-phosphate-adaptor protein 1 and 2 (FAPP1 and FAPP2). [ Godi A et al, FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol. 2004 May;6(5):393-404. ] This three molecule complex recruits proteins that need to be carried to the cell membrane. [ Choudhury RR, Hyvola N, Lowe M. Phosphoinositides and membrane traffic at the trans-Golgi network. Biochem Soc Symp. 2005;(72):31-8. ]
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