Phosphatidylinositol (3,5)-bisphosphate
- Phosphatidylinositol (3,5)-bisphosphate
Phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)"P"2) is a minor phospholipid component of cell membranes, yet important in distinguishing cell compartments. The generation of PtdIns(3,5)"P"2 in internal membranes by the lipid kinase PIKfyve recruits a number of important proteins involved in regulating intracellular trafficking.
PtdIns(3,5)"P"2 is dephophosphorylated by members of the myotubularin lipid phosphatase family on the 3 position of the inositol ring generating Phosphatidylinositol 5-phosphate (PtdIns5"P").
The phosphoinositide-binding domain in a number of proteins binds to PtdIns(3,5)"P"2, including the PH domain in centaurin-β2, the PX domain of SNX1, and a novel domain in Atg18p.
References
*Michell RH, Heath VL, Lemmon MA, Dove SK. (2006) Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. "Trends Biochem Sci". 31(1):52-63. [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCV-4HVDYKK-1&_coverDate=01%2F31%2F2006&_alid=379389085&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5180&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=85744e07280c8bce926a48329b8edd5e]
External links
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