Phosphatidylinositol (4,5)-bisphosphate

Phosphatidylinositol (4,5)-bisphosphate

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ImageFile = Phosphatidylinositol-4,5-bisphosphate.jpg
OtherNames =
Formula = C47H85O19P3
PubChem = 5497157
MolarMass= 1047.09
CASNo = 245126-95-8
Density=
MeltingPt=
BoilingPt=

Phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)"P"2) is a minor phospholipid component of cell membranes. PtdIns(4,5)"P"2 is enriched at the plasma membrane where it is an important substrate for a number of important signaling proteins.cite book | author = Strachan T, Read AP | title = Leptospira. "In:" Human Molecular Genetics | edition = 2nd ed. | publisher = Wiley-Liss | year = 1999 | id = [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hmg.table.888 (via NCBI Bookshelf)] ISBN 0-471-33061-2 ]

Phospholipase C hydrolyzes the phosphodiester link in PtdIns(4,5)"P"2 forming inositol 1,4,5-triphosphate (Ins"P"3) and diacylglycerol (DAG).

PtdIns(4,5)P22 is formed primarily by the type I phosphatidylinositol 4 phosphate 5 kinases from PI(4)P.

Class I PI 3-kinases phosphorylate PtdIns(4,5)"P"2 forming phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)"P"3). Both PtdIns(3,4,5)"P"3 and PtdIns(4,5)"P"2 not only act as substrates for enzymes but also serve as docking phospholipids that bind specific domains that promote the recruitment of proteins to the plasma membrane and subsequent activation of signaling cascades.


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  • Phosphatidylinositol (3,5)-bisphosphate — (PtdIns(3,5) P 2) is a minor phospholipid component of cell membranes, yet important in distinguishing cell compartments. The generation of PtdIns(3,5) P 2 in internal membranes by the lipid kinase PIKfyve recruits a number of important proteins… …   Wikipedia

  • Phosphatidylinositol (3,4)-bisphosphate — (PtdIns(3,4) P 2) is a minor phospholipid component of cell membranes, yet an important second messenger. The generation of PtdIns(3,4) P 2 at the plasma membrane activates a number of important cell signaling pathways. PtdIns(3,4) P 2 is… …   Wikipedia

  • Phosphatidylinositol-4,5-bisphosphate — Strukturformel von PIP2, R steht für die Fettsäurereste Capryl, Oleyl, Palmityl, Arachidonyl oder Stearyl. Die Phosphatidylinositol 4,5 bisphosphate (Abk. PIP2) sind eine Gruppe von Phospholipiden, die nahezu ausschließ …   Deutsch Wikipedia

  • Phosphatidylinositol-3,4-bisphosphate 4-phosphatase — In enzymology, a phosphatidylinositol 3,4 bisphosphate 4 phosphatase (EC number|3.1.3.66) is an enzyme that catalyzes the chemical reaction:1 phosphatidyl myo inositol 3,4 bisphosphate + H2O ightleftharpoons 1 phosphatidyl 1D myo inositol 3… …   Wikipedia

  • Phosphatidylinositol-4,5-bisphosphate 3-kinase — In enzymology, a phosphatidylinositol 4,5 bisphosphate 3 kinase (EC number|2.7.1.153) is an enzyme that catalyzes the chemical reaction:ATP + 1 phosphatidyl 1D myo inositol 4,5 bisphosphate ightleftharpoons ADP + 1 phosphatidyl 1D myo inositol… …   Wikipedia

  • Phosphatidylinositol — (abbreviated PtdIns, or PI) is a minor phospholipid component in the cytosolic side of eukaryotic cell membranes. Being an amphiphile, this molecule possesses polymorphic behaviour, that is currently a topic of research in academic study.… …   Wikipedia

  • Phosphatidylinositol bisphosphate — may refer to: * Phosphatidylinositol (3,4) bisphosphate * Phosphatidylinositol (3,5) bisphosphate * Phosphatidylinositol (4,5) bisphosphate …   Wikipedia

  • Phosphatidylinositol (3,4,5)-trisphosphate — (PtdIns(3,4,5) P 3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3 kinases (PI 3 kinases) activity on phosphatidylinositol (4,5) bisphosphate. PtdIns(3,4,5) P 3 is dephophosphorylated by the phosphatase, PTEN on the …   Wikipedia

  • Phosphatidylinositol 4-phosphate — (PtdIns4 P ) is a precursor of Phosphatidylinositol (4,5) bisphosphate. PtdIns4 P is prevalent in the membrane of the Golgi apparatus.In the Golgi apparatus, PtdIns4 P binds to the GTP binding protein ARF and to effector proteins, including four… …   Wikipedia

  • Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase — In enzymology, a phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase (EC number|3.1.3.67) is an enzyme that catalyzes the chemical reaction:phosphatidylinositol 3,4,5 trisphosphate + H2O ightleftharpoons phosphatidylinositol 4,5 bisphosphate + …   Wikipedia

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