Phosphatidylinositol 3-phosphate
- Phosphatidylinositol 3-phosphate
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OtherNames = sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate
Formula = C11H20O16P2
PubChem = 6857403
SMILES =
MolarMass= 470.214
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Phosphatidylinositol 3-phosphate (PtdIns3"P") is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on Phosphatidylinositol.
PtdIns3"P" is dephophosphorylated by the myotubularin family of phosphatases, on the D3 position of the inositol ring.
The FYVE domain, and the PX domain in a number of proteins binds to PtdIns3"P" include those in SNX1, Hrs, and EEA1.
The majority of PtdIns3"P" appears to be constitutively synthesised by the class III PI 3-kinase, Vps34 at endocytic membranes. Class II PI 3-kinases also appear to synthesise PtdIns3"P", their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3"P" may be synthesised upon cell stimulation.
PtdIns3"P" in cell membranes helps to recruit a range of proteins, many of which are involved in protein trafficking.
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