Melkersson–Rosenthal syndrome

Melkersson–Rosenthal syndrome
Melkersson–Rosenthal syndrome
Classification and external resources
ICD-10 G51.2
ICD-9 351.8
OMIM 155900
DiseasesDB 31963
eMedicine derm/72
MeSH D008556

Melkersson–Rosenthal syndrome is a rare neurological disorder characterized by recurring facial paralysis, swelling of the face and lips (usually the upper lip), and the development of folds and furrows in the tongue.[1]:799 Onset is in childhood or early adolescence. After recurrent attacks (ranging from days to years in between), swelling may persist and increase, eventually becoming permanent. The lip may become hard, cracked, and fissured with a reddish-brown discoloration. The cause of Melkersson–Rosenthal syndrome is unknown, but there may be a genetic predisposition. It can be symptomatic of Crohn's disease or sarcoidosis.

Contents

Treatment

Treatment is symptomatic and may include medication therapies with nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids to reduce swelling, as well as antibiotics and immunosuppressants. Surgery may be recommended to relieve pressure on the facial nerves and to reduce swollen tissue, but its effectiveness has not been established. Massage and electrical stimulation may also be prescribed.

Prognosis

Melkersson–Rosenthal syndrome may recur intermittently after its first appearance. It can become a chronic disorder. Follow-up care should exclude the development of Crohn's disease or sarcoidosis.[citation needed]

Eponym

It is named for Ernst Melkersson and Curt Rosenthal.[2][3][4]

Research

The NINDS supports research on neurological disorders such as Melkersson-Rosenthal syndrome. Much of this research is aimed at increasing knowledge of these disorders and finding ways to treat, prevent, and ultimately cure them.

See also

References

  1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
  2. ^ synd/9 at Who Named It?
  3. ^ Melkersson, E. (1928). "Ett fall av recidiverande facialispares i samband med ett angioneurotiskt ødem". Hygiea (Stockholm) 90: 737–741. 
  4. ^ Rosenthal, C. (1931). "Klinisch-erbbiologischer Beitrag zur Konstitutionspathologie. Gemeinsames Auftreten von Facialislähmung, angioneurotischem Gesichtsödem und Lingua plicata in Arthritismus-Familien". Zeitschrift für die gesamte Neurologie und Psychiatrie 131: 475–501. 

References

en español http://es.wikipedia.org/wiki/Sindrome_Melkersson%E2%80%93Rosenthal




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  • Melkersson-Rosenthal syndrome — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 31963 ICD10 = ICD10|G|51|2|g|50 ICD9 = ICD9|351.8 ICDO = OMIM = 155900 MedlinePlus = eMedicineSubj = derm eMedicineTopic = 72 MeshID = D008556 Melkersson Rosenthal syndrome is a rare… …   Wikipedia

  • Melkersson-Rosenthal syndrome — a rare disorder characterized by the occurrence together of facial paralysis, enlargement of the glottis, and swollen lips, which is due to lymphatic stasis and the consequent build up of protein in the facial tissues. E. Melkersson (1898 1932),… …   Medical dictionary

  • Melkersson-Rosenthal syndrome — a rare disorder characterized by the occurrence together of facial paralysis, enlargement of the glottis, and swollen lips, which is due to lymphatic stasis and the consequent build up of protein in the facial tissues [Melkersson (1898–1932),… …   The new mediacal dictionary

  • Syndrome de Melkersson-Rosenthal — Le syndrome de Melkersson Rosenthal (ou chéilite granulomateuse) est une maladie orpheline débutant dans l enfance. Le syndrome associe des paralysies faciales récidivantes, un œdème facial persistant et des fissures linguales. Aucune cause n est …   Wikipédia en Français

  • Síndrome Melkersson–Rosenthal — Este artículo o sección necesita ser wikificado con un formato acorde a las convenciones de estilo. Por favor, edítalo para que las cumpla. Mientras tanto, no elimines este aviso puesto el 20 de febrero de 2011. También puedes ayudar wikificando… …   Wikipedia Español

  • síndrome de Melkersson-Rosenthal — Eng. Melkersson Rosenthal syndrome Síndrome que se manifiesta en la infancia o en la juventud ocasionado por una alteración de la irrigación del nervio facial de etiología desconocida. Clínicamente se manifiesta como edema crónico facial y labial …   Diccionario de oftalmología

  • Melkersson syndrome — Melkersson Rosenthal syndrome an autosomal dominant condition usually beginning in childhood or adolescence, characterized chiefly by chronic noninflammatory facial swelling, usually confined to the lips in the form of granulomatous cheilitis,… …   Medical dictionary

  • syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting together the picture of the disease. SEE ALSO: disease. [G. s., a running together, tumultuous concourse; (in med.) a concurrence of symptoms, fr. syn,… …   Medical dictionary

  • Melkersson — Ernst G., Swedish physician, 1898–1932. See M. Rosenthal syndrome …   Medical dictionary

  • Rosenthal — Curt, 20th century German psychiatrist. See Melkersson R. syndrome. Friedrich C., German anatomist, 1780–1829. See R. canal, R. vein, basal vein of R …   Medical dictionary

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