Melkersson–Rosenthal syndrome

Melkersson–Rosenthal syndrome
Classification and external resources
ICD-10	G51.2
ICD-9	351.8
OMIM	155900
DiseasesDB	31963
eMedicine	derm/72
MeSH	D008556

Melkersson–Rosenthal syndrome is a rare neurological disorder characterized by recurring facial paralysis, swelling of the face and lips (usually the upper lip), and the development of folds and furrows in the tongue.^[1]:799 Onset is in childhood or early adolescence. After recurrent attacks (ranging from days to years in between), swelling may persist and increase, eventually becoming permanent. The lip may become hard, cracked, and fissured with a reddish-brown discoloration. The cause of Melkersson–Rosenthal syndrome is unknown, but there may be a genetic predisposition. It can be symptomatic of Crohn's disease or sarcoidosis.

Treatment

Treatment is symptomatic and may include medication therapies with nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids to reduce swelling, as well as antibiotics and immunosuppressants. Surgery may be recommended to relieve pressure on the facial nerves and to reduce swollen tissue, but its effectiveness has not been established. Massage and electrical stimulation may also be prescribed.

Prognosis

Melkersson–Rosenthal syndrome may recur intermittently after its first appearance. It can become a chronic disorder. Follow-up care should exclude the development of Crohn's disease or sarcoidosis.^{[citation needed]}

Eponym

It is named for Ernst Melkersson and Curt Rosenthal.^[2][3][4]

Research

The NINDS supports research on neurological disorders such as Melkersson-Rosenthal syndrome. Much of this research is aimed at increasing knowledge of these disorders and finding ways to treat, prevent, and ultimately cure them.

See also

• List of cutaneous conditions

References

1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
2. ^ synd/9 at Who Named It?
3. ^ Melkersson, E. (1928). "Ett fall av recidiverande facialispares i samband med ett angioneurotiskt ødem". Hygiea (Stockholm) 90: 737–741. 
4. ^ Rosenthal, C. (1931). "Klinisch-erbbiologischer Beitrag zur Konstitutionspathologie. Gemeinsames Auftreten von Facialislähmung, angioneurotischem Gesichtsödem und Lingua plicata in Arthritismus-Familien". Zeitschrift für die gesamte Neurologie und Psychiatrie 131: 475–501. 

References

• The original version of this article was taken from the public domain source at http://www.ninds.nih.gov/disorders/melkersson/melkersson.htm

en español http://es.wikipedia.org/wiki/Sindrome_Melkersson%E2%80%93Rosenthal