Melkersson-Rosenthal syndrome
- Melkersson-Rosenthal syndrome
Infobox_Disease
Name = PAGENAME
Caption =
DiseasesDB = 31963
ICD10 = ICD10|G|51|2|g|50
ICD9 = ICD9|351.8
ICDO =
OMIM = 155900
MedlinePlus =
eMedicineSubj = derm
eMedicineTopic = 72
MeshID = D008556
Melkersson-Rosenthal syndrome is a rare neurological disorder characterized by recurring facial paralysis, swelling of the face and lips (usually the upper lip), and the development of folds and furrows in the tongue. Onset is in childhood or early adolescence. After recurrent attacks (ranging from days to years in between), swelling may persist and increase, eventually becoming permanent. The lip may become hard, cracked, and fissured with a reddish-brown discoloration. The cause of Melkersson-Rosenthal syndrome is unknown, but there may be a genetic predisposition. It can be symptomatic of Crohn's disease or sarcoidosis.
Treatment
Treatment is symptomatic and may include medication therapies with nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids to reduce swelling, as well as antibiotics and immunosuppressants. Surgery may be recommended to relieve pressure on the facial nerves and to reduce swollen tissue, but its effectiveness has not been established. Massage and electrical stimulation may also be prescribed.
Prognosis
Melkersson-Rosenthal syndrome may recur intermittently after its first appearance. It can become a chronic disorder. Follow-up care should exclude the development of Crohn's disease or sarcoidosis.
Eponym
It is named for Ernst Melkersson and Curt Rosenthal. [WhoNamedIt|synd|9] [E. Melkersson. Ett fall av recidiverande facialispares i samband med ett angioneurotiskt ødem. Hygiea, Stockholm, 1928, 90: 737-41. ] [C. Rosenthal.Klinisch-erbbiologischer Beitrag zur Konstitutionspathologie. Gemeinsames Auftreten von Facialislähmung, angioneurotischem Gesichtsödem und Lingua plicata in Arthritismus-Familien. Zeitschrift für die gesamte Neurologie und Psychiatrie, 1931, 131: 475-501.]
References
"The original version of this article was taken from the public domain source at http://www.ninds.nih.gov/disorders/melkersson/melkersson.htm"
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Look at other dictionaries:
Melkersson–Rosenthal syndrome — Classification and external resources ICD 10 G51.2 ICD 9 351.8 … Wikipedia
Melkersson-Rosenthal syndrome — a rare disorder characterized by the occurrence together of facial paralysis, enlargement of the glottis, and swollen lips, which is due to lymphatic stasis and the consequent build up of protein in the facial tissues. E. Melkersson (1898 1932),… … Medical dictionary
Melkersson-Rosenthal syndrome — a rare disorder characterized by the occurrence together of facial paralysis, enlargement of the glottis, and swollen lips, which is due to lymphatic stasis and the consequent build up of protein in the facial tissues [Melkersson (1898–1932),… … The new mediacal dictionary
Syndrome de Melkersson-Rosenthal — Le syndrome de Melkersson Rosenthal (ou chéilite granulomateuse) est une maladie orpheline débutant dans l enfance. Le syndrome associe des paralysies faciales récidivantes, un œdème facial persistant et des fissures linguales. Aucune cause n est … Wikipédia en Français
Síndrome Melkersson–Rosenthal — Este artículo o sección necesita ser wikificado con un formato acorde a las convenciones de estilo. Por favor, edítalo para que las cumpla. Mientras tanto, no elimines este aviso puesto el 20 de febrero de 2011. También puedes ayudar wikificando… … Wikipedia Español
síndrome de Melkersson-Rosenthal — Eng. Melkersson Rosenthal syndrome Síndrome que se manifiesta en la infancia o en la juventud ocasionado por una alteración de la irrigación del nervio facial de etiología desconocida. Clínicamente se manifiesta como edema crónico facial y labial … Diccionario de oftalmología
Melkersson syndrome — Melkersson Rosenthal syndrome an autosomal dominant condition usually beginning in childhood or adolescence, characterized chiefly by chronic noninflammatory facial swelling, usually confined to the lips in the form of granulomatous cheilitis,… … Medical dictionary
syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting together the picture of the disease. SEE ALSO: disease. [G. s., a running together, tumultuous concourse; (in med.) a concurrence of symptoms, fr. syn,… … Medical dictionary
Melkersson — Ernst G., Swedish physician, 1898–1932. See M. Rosenthal syndrome … Medical dictionary
Rosenthal — Curt, 20th century German psychiatrist. See Melkersson R. syndrome. Friedrich C., German anatomist, 1780–1829. See R. canal, R. vein, basal vein of R … Medical dictionary
