Lamivudine/zidovudine

Lamivudine/zidovudine

Combination of
Lamivudine	Nucleoside analogue reverse transcriptase inhibitor
Zidovudine	Nucleoside analogue reverse transcriptase inhibitor
Clinical data
MedlinePlus	a601066
Pregnancy cat.	C(US)
Legal status	POM (UK) ℞-only (US)
Routes	Oral
Identifiers
ATC code	J05AR01
PubChem	CID 160352
ChemSpider	21106283 Y
Y(what is this?)  (verify)

Lamivudine/zidovudine (INNs, trade name Combivir) is a pharmaceutical treatment for HIV infection. It is a fixed dose combination of two antiretroviral drugs, lamivudine (also called 3TC, with the brand name Epivir) and zidovudine (also called AZT, with the brand name Retrovir). The combination of the two drugs has a stronger and more sustained effect than using either drug alone, and assists in reducing pill burden and in aiding compliance with the antiretroviral drug therapy.

Both lamivudine and zidovudine are reverse transcriptase inhibitors, which block the action of an enzyme, reverse transcriptase, that the virus requires for reproduction. It reduces the viral load in the body and raises CD4 cell count.

It was approved for use in the United States by the Food and Drug Administration on September 26, 1997, making it the thirteenth approved antiretroviral. It is marketed by ViiV Healthcare.

Combivir users typically report feeling tired and sick.^{[citation needed]}

External links

• Combivir website operated by GlaxoSmithKline

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Fixed dose combination (antiretroviral) World Health Organization essential medicines Antiinfective agent stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Ipratropium bromide/salbutamol M1870 Belgian Comblain Look at other dictionaries: Zidovudine — AZT redirects here. For other uses, see AZT (disambiguation). Zidovudine Systematic (IUPAC) name …   Wikipedia Lamivudine — Général Nom IUPAC (2R,5S) (–) 4 amino 1 [2 (hydroxymethyl) 1,3 oxathiolan 5 yl] 1H pyrimidin 2 one Syno …   Wikipédia en Français Lamivudine — Drugbox IUPAC name = L 2 ,3 dideoxy 3 thiacytidine CAS number=134678 17 4 ATC prefix=J05 ATC suffix=AF05 ATC supplemental= PubChem=60825 DrugBank=APRD00681 C=8 | H=11 | N=3 | O=3 | S=1 molecular weight = 229.26 g/mol smiles = Nc1ccn( [C@@H] 2CS… …   Wikipedia Zidovudine — Pour les articles homonymes, voir AZT. Zidovudine …   Wikipédia en Français lamivudine — la·miv·u·dine lə miv yü .dēn n an antiviral drug C8H11N3O3S that is a synthetic nucleoside analog acting against HIV by inhibiting reverse transcriptase see EPIVIR * * * n. a reverse transcriptase inhibitor (see reverse transcriptase). * * *… …   Medical dictionary lamivudine — noun a nucleoside reverse transcriptase inhibitor that is very effective in combination with zidovudine in treating AIDS and HIV • Syn: ↑3TC • Hypernyms: ↑nucleoside reverse transcriptase inhibitor, ↑NRTI …   Useful english dictionary Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors — (NRTIs and NtRTIs) began in the 1980s when the AIDS epidemic hit Western societies. NRTIs inhibit the reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of the human immunodeficiency virus (HIV). The first …   Wikipedia Antiretroviral drug — HAART redirects here. For UK estate agency Haart, see Spicerhaart. Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. When several such drugs, typically three or four, are taken in combination, the …   Wikipedia Reverse-transcriptase inhibitor — Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tumors,[1] and cancer.[2] RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase enzyme that retroviruses need to reproduce.… …   Wikipedia Nevirapine — Systematic (IUPAC) name 11 cyclopropyl 4 methyl 5,11 d …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”