- Gp41
protein
Name = HIV gp41
caption = HIV gp41
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LocusSupplementaryData =gp41 is a
glycoprotein non-covalently-bound to gp120, and provides the second step by which HIV enters the cell. It is originally buried within the viral envelope, but, when gp120 binds to a CD4 receptor, gp120 changes its conformation, causing gp41 to become exposed, where it can assist in fusion with the host cell.Fusion inhibitor drugs such asenfuvirtide block the fusion process by binding to gp41.The "env" gene does not, in fact, code for gp120 and gp41, but for a precursor to both, gp160. During
HIV reproduction, the host cell's own enzymes cleave gp160 into gp120 and gp41. See Replication cycle of HIV.A polyclonal caprine antibody is in phase II human
clinical trial s that targets, among others sites, the GP41 transmembrane glycoprotein. This is a new class of treatment for HIV infection. The trials are being conducted for a patented biologic developed by Virionyx, a New Zealand Company. [cite web |url=http://www.virionyx.com |title=virionyx.com |accessdate=2007-08-26 |format= |work=]ee also
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HIV structure and genome References
External links
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