Amprenavir

Amprenavir

drugbox
IUPAC_name = tetrahydrofuran-3-yl [3- [(4-aminophenyl)sulfonyl- (2-methylpropyl) amino] -1-benzyl-2- hydroxy-propyl] aminomethanoate


CAS_number = 161814-49-9
ATC_prefix = J05
ATC_suffix = AE05
ATC_supplemental =
PubChem = 65016
DrugBank = APRD00605
C=25 | H=35 | N=3 | O=6 | S=1
molecular_weight = 505.628 g/mol
bioavailability =
protein_bound = 90%
metabolism = hepatic
excretion = <3% renal
elimination_half-life = 7.1-10.6 hours
licence_EU = Agenerase
licence_US = Amprenavir
pregnancy_US = C
pregnancy_category =
legal_status =
routes_of_administration = oral

Amprenavir (Agenerase, GlaxoSmithKline) is a protease inhibitor used to treat HIV infection. It was approved by the Food and Drug Administration on April 15, 1999, for twice-a-day dosing instead of needing to be taken every eight hours. The convenient dosing came at a price, as the dose required is 1,200mg, delivered in eight very large gel capsules.

Production of amprenavir was discontinued by the manufacturer December 31, 2004; a prodrug version (fosamprenavir) is available.

See also

* Fosamprenavir, a prodrug of amprenavir



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  • Amprenavir — Strukturformel Allgemeines Freiname Amprenavir Andere Namen …   Deutsch Wikipedia

  • amprenavir — noun An anti retroviral drug of the protease inhibitor class that is used in to treat HIV infected patients …   Wiktionary

  • amprenavir — am·pren·a·vir (am prenґə vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used in treatment of human immunodeficiency virus infection; administered orally …   Medical dictionary

  • Discovery and development of HIV-protease inhibitors — Many major physiological processes depend on regulation of proteolytic enzyme activity and there can be dramatic consequences when equilibrium between an enzyme and its substrates is disturbed. In this prospective, the discovery of small molecule …   Wikipedia

  • Fosamprenavir — Drugbox IUPAC name = [(2 R ,3 S ) 1 [(4 aminophenyl)sulfonyl (2 methyl propyl)amino] 3 { [(3 S ) oxolan 3 yl] oxycarbonylamino} 4 phenyl butan 2 yl] oxyphosphonic acid CAS number=226700 81 8 ATC prefix=J05 ATC suffix=AE07 PubChem=131536 DrugBank …   Wikipedia

  • Fosamprenavir — Strukturformel Allgemeines Freiname Fosamprenavir Andere Namen …   Deutsch Wikipedia

  • Protease-Inhibitor — Protease Inhibitoren (PI) sind Moleküle, die Peptidasen (alter Name: Proteasen) hemmen und damit den Abbau von Proteinen verhindern können. Oft handelt es sich dabei selbst um Proteine. Auch eine Gruppe von Arzneistoffen, die zur Behandlung von… …   Deutsch Wikipedia

  • Proteasehemmer — Protease Inhibitoren (PI) sind Moleküle, die Peptidasen (alter Name: Proteasen) hemmen und damit den Abbau von Proteinen verhindern können. Oft handelt es sich dabei selbst um Proteine. Auch eine Gruppe von Arzneistoffen, die zur Behandlung von… …   Deutsch Wikipedia

  • Proteaseinhibitor — Protease Inhibitoren (PI) sind Moleküle, die Peptidasen (alter Name: Proteasen) hemmen und damit den Abbau von Proteinen verhindern können. Oft handelt es sich dabei selbst um Proteine. Auch eine Gruppe von Arzneistoffen, die zur Behandlung von… …   Deutsch Wikipedia

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