Tre recombinase

Tre recombinase

Tre recombinase is an experimental enzyme that in lab tests has successfully removed DNA inserted by HIV from infected cells [Sarkar, I." et al." (2007): "HIV-1 proviral DNA excision using an evolved recombinase." In: "Science." Bd. 316, S. 1912-1915. PMID 17600219 DOI|10.1126/science.1141453] . The enzyme was derived from Cre recombinase through selective mutation for the purposes of identifying HIV markers, which are not bounded by loxP sites and therefore disallow attempts at Cre-Lox recombination.


External links

* [ Designer Enzyme Cuts HIV Out of Infected Cells]
* [ Potential cure for HIV discovered] Dead link|date=June 2008
* [ HIV-1 Proviral DNA Excision Using an Evolved Recombinase]

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