Clevudine

Clevudine
Clevudine
Systematic (IUPAC) name
1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5- (hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine- 2,4-dione
Clinical data
Pregnancy cat.  ?
Legal status  ?
Routes Oral
Identifiers
CAS number 69256-17-3 YesY
ATC code J05AF12 [1]
PubChem CID 73115
UNII IN51MVP5F1 N
KEGG D03537 YesY
ChEMBL CHEMBL458875 N
Chemical data
Formula C10H13FN2O5 
Mol. mass 260.219 g/mol
 N(what is this?)  (verify)

Clevudine (INN) is an antiviral drug for the treatment of hepatitis B. Clevudine is already approved for HBV in South Korea and the Philippines. It is marketed by Bukwang pharmaceuticals in South Korea under the tradenames Levovir and Revovir. Under license from Bukwang, Pharmasset was developing the drug, but its phase III clinical trial (international, multicenter, randomized, double-blind, 96 week QUASH studies) was terminated due to some myopathy cases in patients.

It is a nucleoside analog.[2]

References

  1. ^ WHO International Working Group for Drug Statistics Methodology (August 27, 2008). "ATC/DDD Classification (FINAL): New ATC 5th level codes". WHO Collaborating Centre for Drug Statistics Methodology. Archived from the original on 2008-05-06. http://web.archive.org/web/20080506023243/http://www.whocc.no/atcddd/new_atc_ddd.html#ATCDDD_FINAL. Retrieved 2008-09-05. 
  2. ^ Lee HS, Chung YH, Lee K, et al. (May 2006). "A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B". Hepatology 43 (5): 982–8. doi:10.1002/hep.21166. PMID 16628625. 
v · d · eDNA virus antivirals (primarily J05, also S01AD and D06BB)
Baltimore I
DNA-synthesis
inhibitor
TK activated
Not TK activated
Other
Imiquimod/Resiquimod • Podophyllotoxin
Hepatitis B (VII)

Nucleoside analogues/NARTIs: Entecavir • Lamivudine • Telbivudine • Clevudine

Nucleotide analogues/NtRTIs: Adefovir • Tenofovir
Multiple/general
Nucleic acid inhibitors
Multiple/unknown
ErbB2/PI3K Pathway
NOV-205§ • NOV-002†

M: VIR

virs(prot)/clss

cutn/syst (hppv/hiva, infl/zost/zoon)/epon

drugJ(dnaa, rnaa, rtva, vacc)


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