Trifluridine

drugbox
IUPAC_name = 1- [4-hydroxy-5-(hydroxymethyl)oxolan-2-yl] -5- (trifluoromethyl) pyrimidine-2,4-dione

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width = 150
CAS_number = 70-00-8
ATC_prefix = S01
ATC_suffix = AD02
PubChem = 6256
DrugBank = APRD01275
C = 10 | H = 11 | F = 3 | N = 2 | O = 5
molecular_weight = 296.2 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life = 12 minutes
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category =
legal_AU =
legal_UK =
legal_US =
legal_status = Rx-only
routes_of_administration = Eye drops

Trifluridine is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by Monarch Pharmaceuticals, which is wholly owned by King Pharmaceuticals.

It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF₃ group added to the uracil component blocks base pairing.

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