- Methisazone
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Methisazone [(1-Methyl-2-oxoindol-3-ylidene)amino]thioureaOther namesMetisazoneIdentifiers CAS number 1910-68-5 PubChem 6861563 UNII K3QML4J07E ChEMBL CHEMBL1512080 Jmol-3D images Image 1 - CN1C2=CC=CC=C2C(=NNC(=S)N)C1=O
Properties Molecular formula C10H10N4OS Molar mass 234.28 g/mol (verify) (what is:
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)Infobox references Methisazone is an antiviral drug that works by inhibiting mRNA and protein synthesis, especially in pox viruses. It has been used in the past to treat smallpox.[1]
Methisazone has been described as being used in prophylaxis since at least 1965.[2][3]
References
- ^ Methisazone, Merriam-Webster's Medical Dictionary
- ^ do Valle, LA; de Melo, PR; de Gomes, LF; Proença, LM (13 Nov 1965). "Methisazone in prevention of variola minor among contacts". Lancet 2 (7420): 976–8. PMID 4159212.
- ^ Weiss MM, Weiss PD, Mathisen G, Guze P (December 2004). "Rethinking smallpox". Clin. Infect. Dis. 39 (11): 1668–73. doi:10.1086/425745. PMID 15578369. http://www.journals.uchicago.edu/cgi-bin/resolve?CID34015.
DNA virus antivirals (primarily J05, also S01AD and D06BB) Baltimore I DNA-synthesis
inhibitorTK activatedguanine (Aciclovir#/Valacyclovir, Ganciclovir/Valganciclovir, Penciclovir/Famciclovir)
adenine (Vidarabine)Not TK activatedOtherMethisazoneHepatitis B (VII) Nucleoside analogues/NARTIs: Entecavir • Lamivudine • Telbivudine • Clevudine
Nucleotide analogues/NtRTIs: Adefovir • TenofovirMultiple/general Nucleic acid inhibitorsMultiple/unknownErbB2/PI3K PathwayNOV-205§ • NOV-002†This antiinfective drug article is a stub. You can help Wikipedia by expanding it.