Famciclovir

Famciclovir

drugbox
IUPAC_name = [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)-butyl] acetate



CAS_number = 104227-87-4
ATC_prefix = J05
ATC_suffix = AB09
ATC_supplemental = ATC|S01|AD07
PubChem = 3324
DrugBank = APRD00600
C=14 | H=19 | N=5 | O=4
molecular_weight = 321.332 g/mol
melting_point = 103
bioavailability = 75–77%
protein_bound = 20-25%
metabolism = Hepatic, circulation, intestinal wall (to penciclovir)
elimination_half-life = 2–2.3 hours
excretion = Renal, faecal
pregnancy_category = B1 (Au), B (U.S.)
legal_status = S4 (Au), POM (UK), ℞-only (U.S.)
routes_of_administration = Oral

Famciclovir (INN) (pronEng|fæmˈsaɪkloʊvɪr) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Schering-Plough).

On August 24, 2007, the United States Food and Drug Administration approved the first generic version of famciclovir. Generic Famciclovir Tablets (125 mg, 250 mg, 500 mg) are manufactured by Kfar-Sava, Israel-based TEVA Pharmaceuticals. [cite web |url=http://www.tevausa.com/default.aspx?pageid=75 |title=Recent Product Launches, Teva Pharmaceuticals USA |accessdate=2008-02-21 |format= |work=]

Clinical use

Indications and dosage forms

Famciclovir comes as a tablet to take by mouth. It is usually taken every 8 hours (three times a day) for 7 days to treat shingles. To treat genital herpes it is usually taken twice a day for 5 days.cite web|url=http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a694038.html |title=MedlinePlus Drug Information: Famciclovir|accessdate=2007-06-12|format=HTML] It is also sometimes given in one single large dose as opposed to several days of scheduled small doses. Among other side effects, Famciclovir may cause an upset stomach. Take famciclovir with food or milk.

Adverse effects

Side effects: mild to extreme stomach upset, headaches, mild fever.

Footnotes

External links

* [http://www.famvir.com Famvir product website run by Schering-Plough]

ee also

*Penciclovir


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • famciclovir — fármaco anviríco utilizado en el tratamiento del Herpes zoster y herpes genital estructura química [véase http://www.iqb.es/diccio/f/fa.htm#famciclovir] Diccionario ilustrado de Términos Médicos.. Alvaro Galiano. 2010 …   Diccionario médico

  • Famciclovir — FCV Général Nom IUPAC diacétyl 6 désoxy 9 (4 hydroxy 3 hydroxyméthyl but 1 yl)guanine …   Wikipédia en Français

  • Famciclovir — Strukturformel Allgemeines Freiname Famciclovir …   Deutsch Wikipedia

  • famciclovir — Eng. Famciclovir Fármaco antivírico análogo al aciclovir aunque efectivo a dosis más bajas y con una menor incidencia de neuralgia postherpética, utilizado en el herpes zoster de la rama oftálmica del trigémino …   Diccionario de oftalmología

  • famciclovir — noun A guanine analogue antiviral drug, a prodrug form of penciclovir, used for the treatment of herpesvirus infections such as shingles …   Wiktionary

  • famciclovir — fam·ci·clo·vir .fam sī klō .vir n a precursor C14H19N5O4 of the antiviral agent penciclovir that after oral administration is converted to penciclovir by cellular kinases and that is used esp. to treat shingles and herpes genitalis see famvir * * …   Medical dictionary

  • 104227-87-4 — Famciclovir Famciclovir FCV Général Nom IUPAC Diacetyl 6 deoxy 9 (4 hydroxy 3 hydroxymethyl but 1 yl)guanine …   Wikipédia en Français

  • C14H19N5O4 — Famciclovir Famciclovir FCV Général Nom IUPAC Diacetyl 6 deoxy 9 (4 hydroxy 3 hydroxymethyl but 1 yl)guanine …   Wikipédia en Français

  • Hepatite B — Hépatite B L hépatite B est une hépatite virale due à une infection par le virus de l hépatite B (VHB) et entrainant une inflammation du foie. Les symptômes de la maladie aiguë sont essentiellement une inflammation du foie, avec ou sans ictère et …   Wikipédia en Français

  • Hépathite B — Hépatite B L hépatite B est une hépatite virale due à une infection par le virus de l hépatite B (VHB) et entrainant une inflammation du foie. Les symptômes de la maladie aiguë sont essentiellement une inflammation du foie, avec ou sans ictère et …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”